ID   ALLA_SCHPO              Reviewed;         191 AA.
AC   O13843;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Ureidoglycolate lyase;
DE            EC=4.3.2.3;
DE   AltName: Full=Ureidoglycolatase;
GN   ORFNames=SPAC19G12.04;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Catalyzes the catabolism of the allantoin degradation
CC       intermediate (S)-ureidoglycolate, generating urea and glyoxylate.
CC       Involved in the utilization of allantoin as secondary nitrogen source
CC       when primary sources are limiting (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-ureidoglycolate = glyoxylate + urea; Xref=Rhea:RHEA:11304,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:36655, ChEBI:CHEBI:57296; EC=4.3.2.3;
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ureidoglycolate lyase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329670; CAB10115.1; -; Genomic_DNA.
DR   PIR; T37991; T37991.
DR   RefSeq; NP_594419.1; NM_001019848.2.
DR   AlphaFoldDB; O13843; -.
DR   SMR; O13843; -.
DR   BioGRID; 278931; 3.
DR   STRING; 4896.SPAC19G12.04.1; -.
DR   iPTMnet; O13843; -.
DR   MaxQB; O13843; -.
DR   PaxDb; O13843; -.
DR   PRIDE; O13843; -.
DR   EnsemblFungi; SPAC19G12.04.1; SPAC19G12.04.1:pep; SPAC19G12.04.
DR   GeneID; 2542470; -.
DR   KEGG; spo:SPAC19G12.04; -.
DR   PomBase; SPAC19G12.04; -.
DR   VEuPathDB; FungiDB:SPAC19G12.04; -.
DR   eggNOG; ENOG502S1JQ; Eukaryota.
DR   HOGENOM; CLU_070848_0_1_1; -.
DR   InParanoid; O13843; -.
DR   OMA; WNIFRCS; -.
DR   PhylomeDB; O13843; -.
DR   UniPathway; UPA00395; -.
DR   PRO; PR:O13843; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0004848; F:ureidoglycolate hydrolase activity; IEA:InterPro.
DR   GO; GO:0050385; F:ureidoglycolate lyase activity; ISO:PomBase.
DR   GO; GO:0000256; P:allantoin catabolic process; ISO:PomBase.
DR   GO; GO:0006145; P:purine nucleobase catabolic process; ISS:PomBase.
DR   Gene3D; 2.60.120.480; -; 1.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   InterPro; IPR007247; Ureidogly_lyase.
DR   InterPro; IPR024060; Ureidoglycolate_lyase_dom_sf.
DR   PANTHER; PTHR21221; PTHR21221; 1.
DR   Pfam; PF04115; Ureidogly_lyase; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   3: Inferred from homology;
KW   Lyase; Purine metabolism; Reference proteome.
FT   CHAIN           1..191
FT                   /note="Ureidoglycolate lyase"
FT                   /id="PRO_0000120561"
SQ   SEQUENCE   191 AA;  20890 MW;  7E5F412FD013DF6F CRC64;
     MEAKKIYAQA LTDEAFAPFG SVVQQKDDVK MVSANGGTAK KYLKVSESIQ NYEKSSSAST
     RKGVWNFFST HPSVHPANDE HAAFQISVLE RHPFTTQTFI PMCRSSDEQA YLIAVAPNAP
     DGMPDWNQTQ AFVAKGAQGV TYSAGVWHAP MVTIGKETML AAFNYENGVA EDDCQVQSTE
     SPIEVFIKIS T