ID   GCH3_METM6              Reviewed;         266 AA.
AC   A9A6P4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=GTP cyclohydrolase III {ECO:0000255|HAMAP-Rule:MF_00608};
DE            EC=3.5.4.29 {ECO:0000255|HAMAP-Rule:MF_00608};
GN   Name=gch3 {ECO:0000255|HAMAP-Rule:MF_00608}; OrderedLocusNames=MmarC6_0505;
OS   Methanococcus maripaludis (strain C6 / ATCC BAA-1332).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=444158;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6 / ATCC BAA-1332;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B.,
RA   Richardson P.;
RT   "Complete sequence of Methanococcus maripaludis C6.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of 2-amino-5-formylamino-6-
CC       ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and
CC       inorganic phosphate from GTP. Also has an independent pyrophosphate
CC       phosphohydrolase activity. {ECO:0000255|HAMAP-Rule:MF_00608}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-
CC         ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate;
CC         Xref=Rhea:RHEA:22468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57258; EC=3.5.4.29;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00608};
CC   -!- SIMILARITY: Belongs to the archaeal-type GTP cyclohydrolase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00608}.
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DR   EMBL; CP000867; ABX01322.1; -; Genomic_DNA.
DR   RefSeq; WP_012193290.1; NC_009975.1.
DR   AlphaFoldDB; A9A6P4; -.
DR   SMR; A9A6P4; -.
DR   STRING; 444158.MmarC6_0505; -.
DR   EnsemblBacteria; ABX01322; ABX01322; MmarC6_0505.
DR   GeneID; 5738538; -.
DR   KEGG; mmx:MmarC6_0505; -.
DR   eggNOG; arCOG04202; Archaea.
DR   HOGENOM; CLU_080076_0_0_2; -.
DR   OMA; VQIAHID; -.
DR   OrthoDB; 56576at2157; -.
DR   PhylomeDB; A9A6P4; -.
DR   GO; GO:0043740; F:GTP cyclohydrolase IIa activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   HAMAP; MF_00608; GTP_cyclohydro_3; 1.
DR   InterPro; IPR007839; GTP_CycHdrlase_3.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   PANTHER; PTHR42202; PTHR42202; 1.
DR   Pfam; PF05165; GCH_III; 1.
DR   PIRSF; PIRSF009265; GTP_cyclohydro_3; 1.
PE   3: Inferred from homology;
KW   Hydrolase.
FT   CHAIN           1..266
FT                   /note="GTP cyclohydrolase III"
FT                   /id="PRO_1000130343"
SQ   SEQUENCE   266 AA;  30072 MW;  D76E5A176AFA3E9C CRC64;
     MIQITVVQID NYGPWTVTPN PRRESDLQAL QSRLYCDMNL QFGAHRGLAF YTRFDNIIAI
     TNGIDLETHK RIQNSVKNRY PFTVSMAVAS AETAYEAQKL ATETIQEYGS AQDDVRKEVL
     DVANEFVSNG YVQLAHVDIN DITGKLTDLE TAYDTYLSVQ MTKLKLMEEL KKYDSMGFFI
     GGDNFMCPCN GMSEKDFLCM FEDIKESCGI DLKAGIGIGK TAEDASNLAD IGLEVIREGK
     TDFQVYTLKQ EIEERKDVTY NYMCPI