ID   GCH42_BURCC             Reviewed;         316 AA.
AC   B1K5N3;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=GTP cyclohydrolase FolE2 2 {ECO:0000255|HAMAP-Rule:MF_01527};
DE            EC=3.5.4.16 {ECO:0000255|HAMAP-Rule:MF_01527};
GN   Name=folE2-2 {ECO:0000255|HAMAP-Rule:MF_01527};
GN   OrderedLocusNames=Bcenmc03_4937;
OS   Burkholderia cenocepacia (strain MC0-3).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=406425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC0-3;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S.,
RA   Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 2 of Burkholderia cenocepacia MC0-3.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts GTP to 7,8-dihydroneopterin triphosphate.
CC       {ECO:0000255|HAMAP-Rule:MF_01527}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate +
CC         H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:37565, ChEBI:CHEBI:58462; EC=3.5.4.16;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01527};
CC   -!- PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate
CC       biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_01527}.
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase IV family.
CC       {ECO:0000255|HAMAP-Rule:MF_01527}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACA94067.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000959; ACA94067.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; B1K5N3; -.
DR   SMR; B1K5N3; -.
DR   EnsemblBacteria; ACA94067; ACA94067; Bcenmc03_4937.
DR   KEGG; bcm:Bcenmc03_4937; -.
DR   HOGENOM; CLU_062816_0_0_4; -.
DR   UniPathway; UPA00848; UER00151.
DR   Proteomes; UP000002169; Chromosome 2.
DR   GO; GO:0003934; F:GTP cyclohydrolase I activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035998; P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01527_B; GTP_cyclohydrol_B; 1.
DR   InterPro; IPR022838; GTP_cyclohydrolase_FolE2.
DR   InterPro; IPR003801; GTP_cyclohydrolase_FolE2/MptA.
DR   PANTHER; PTHR36445; PTHR36445; 1.
DR   Pfam; PF02649; GCHY-1; 1.
PE   3: Inferred from homology;
KW   Hydrolase.
FT   CHAIN           1..316
FT                   /note="GTP cyclohydrolase FolE2 2"
FT                   /id="PRO_0000372023"
FT   SITE            166
FT                   /note="May be catalytically important"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01527"
SQ   SEQUENCE   316 AA;  34116 MW;  B9DAFA99C8F154D6 CRC64;
     MEKALHRISS MNAALPDISL TDAAPGRRPL EWVGMQGIDL PVVVAEPGCR RDVHARADVQ
     VDLPAPQVKG IHMSRLYGLL DGLADGEALS PAGLQRMLRA MVDSHRDCAT RSARVRLRFD
     LLARRTALVT EGLAGWKAYP VRLDATLSGD AFALRAQVTV VYSSTCPCSA ALSRHWIEQA
     FLTAFGHEAR VEPTAVAAWL KRHATAATPH SQRSEAVVSV ALPADGTTLG LLDLIDRVEQ
     ALGTPVQTAV KRADEQAFAV LNGGNLMFVE DAARRVQAAL EDRHASPRVR VRHLESLHPH
     DAVAWAAPLR EGADAC