GCH4_BURM1
ID GCH4_BURM1 Reviewed; 269 AA.
AC A9ANA1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=GTP cyclohydrolase FolE2 {ECO:0000255|HAMAP-Rule:MF_01527};
DE EC=3.5.4.16 {ECO:0000255|HAMAP-Rule:MF_01527};
GN Name=folE2 {ECO:0000255|HAMAP-Rule:MF_01527};
GN OrderedLocusNames=Bmul_4819, BMULJ_03697;
OS Burkholderia multivorans (strain ATCC 17616 / 249).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=395019;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17616 / 249;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J.,
RA Richardson P.;
RT "Complete sequence of chromosome 2 of Burkholderia multivorans ATCC
RT 17616.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17616 / 249;
RA Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E.,
RA Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N.,
RA Hattori M., Tsuda M.;
RT "Complete genome sequence of Burkholderia multivorans ATCC 17616.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Converts GTP to 7,8-dihydroneopterin triphosphate.
CC {ECO:0000255|HAMAP-Rule:MF_01527}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate +
CC H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15740, ChEBI:CHEBI:37565, ChEBI:CHEBI:58462; EC=3.5.4.16;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01527};
CC -!- PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate
CC biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_01527}.
CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase IV family.
CC {ECO:0000255|HAMAP-Rule:MF_01527}.
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DR EMBL; CP000869; ABX18490.1; -; Genomic_DNA.
DR EMBL; AP009386; BAG45569.1; -; Genomic_DNA.
DR RefSeq; WP_012217400.1; NC_010805.1.
DR AlphaFoldDB; A9ANA1; -.
DR SMR; A9ANA1; -.
DR STRING; 395019.Bmul_4819; -.
DR EnsemblBacteria; BAG45569; BAG45569; BMULJ_03697.
DR KEGG; bmj:BMULJ_03697; -.
DR KEGG; bmu:Bmul_4819; -.
DR eggNOG; COG1469; Bacteria.
DR HOGENOM; CLU_062816_1_1_4; -.
DR OMA; PCSQGMS; -.
DR UniPathway; UPA00848; UER00151.
DR Proteomes; UP000008815; Chromosome 2.
DR GO; GO:0003934; F:GTP cyclohydrolase I activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035998; P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01527_B; GTP_cyclohydrol_B; 1.
DR InterPro; IPR022838; GTP_cyclohydrolase_FolE2.
DR InterPro; IPR003801; GTP_cyclohydrolase_FolE2/MptA.
DR PANTHER; PTHR36445; PTHR36445; 1.
DR Pfam; PF02649; GCHY-1; 1.
PE 3: Inferred from homology;
KW Hydrolase; Reference proteome.
FT CHAIN 1..269
FT /note="GTP cyclohydrolase FolE2"
FT /id="PRO_0000372024"
FT SITE 154
FT /note="May be catalytically important"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01527"
SQ SEQUENCE 269 AA; 30105 MW; B98650930DFE6AF9 CRC64;
MNQMNPAFVM PDVQSTVDTR QIPIQRVGVK AVRHPLTVLT ESGDVQPTVG VWNLDVRLPA
EQKGTHMSRF VALLEENRAP LTIERFRAMI ASMLEKLEAE AGRIEVTFPY FVNKTAPVSG
VQSLLDYEVT LAGESRNGDT RLFLKVLVPV TSLCPCSKKI SQYGAHNQRS HVTIDAELAA
DVPVEALIRI AEEEASCELW GLLKRPDEKF VTERAYENPK FVEDLVRDVA ARLDADARIV
AYVLEAENFE SIHNHSAYAL IERDKRHAA
