GCH4_RALSO
ID GCH4_RALSO Reviewed; 268 AA.
AC Q8XX96;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=GTP cyclohydrolase FolE2 {ECO:0000255|HAMAP-Rule:MF_01527};
DE EC=3.5.4.16 {ECO:0000255|HAMAP-Rule:MF_01527};
GN Name=folE2 {ECO:0000255|HAMAP-Rule:MF_01527}; OrderedLocusNames=RSc2220;
GN ORFNames=RS01379;
OS Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Ralstonia.
OX NCBI_TaxID=267608;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GMI1000;
RX PubMed=11823852; DOI=10.1038/415497a;
RA Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL Nature 415:497-502(2002).
CC -!- FUNCTION: Converts GTP to 7,8-dihydroneopterin triphosphate.
CC {ECO:0000255|HAMAP-Rule:MF_01527}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate +
CC H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15740, ChEBI:CHEBI:37565, ChEBI:CHEBI:58462; EC=3.5.4.16;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01527};
CC -!- PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate
CC biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_01527}.
CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase IV family.
CC {ECO:0000255|HAMAP-Rule:MF_01527}.
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DR EMBL; AL646052; CAD15927.1; -; Genomic_DNA.
DR RefSeq; WP_011002148.1; NC_003295.1.
DR AlphaFoldDB; Q8XX96; -.
DR SMR; Q8XX96; -.
DR STRING; 267608.RSc2220; -.
DR EnsemblBacteria; CAD15927; CAD15927; RSc2220.
DR GeneID; 60501733; -.
DR KEGG; rso:RSc2220; -.
DR eggNOG; COG1469; Bacteria.
DR HOGENOM; CLU_062816_1_1_4; -.
DR OMA; PCSQGMS; -.
DR UniPathway; UPA00848; UER00151.
DR Proteomes; UP000001436; Chromosome.
DR GO; GO:0003934; F:GTP cyclohydrolase I activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035998; P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01527_B; GTP_cyclohydrol_B; 1.
DR InterPro; IPR022838; GTP_cyclohydrolase_FolE2.
DR InterPro; IPR003801; GTP_cyclohydrolase_FolE2/MptA.
DR PANTHER; PTHR36445; PTHR36445; 1.
DR Pfam; PF02649; GCHY-1; 1.
PE 3: Inferred from homology;
KW Hydrolase; Reference proteome.
FT CHAIN 1..268
FT /note="GTP cyclohydrolase FolE2"
FT /id="PRO_0000147722"
FT SITE 153
FT /note="May be catalytically important"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01527"
SQ SEQUENCE 268 AA; 30200 MW; 5987B6E33DC2A7E2 CRC64;
MNDMNPGFVM PDVQSSHDTR QIPIQRVGVR GVRYPMSLQT PSGVLSTVGT FNLDVHLPAD
QKGTHMSRFV ALLEEEREPL NLAQFQLLLE KMLEKLEADA GRIEVSFPYF VSKTAPVSGV
QSLMDYEVTM IGEVRDGHTT VRVKALVPVT SLCPCSKKIS QYGAHNQRSH ITIDAELAAD
TPVEALIRMA EEEASCELWG LLKRPDEKFV TERAYENPKF VEDLVRDIAM RLNEDDRIVA
YTLEAENFES IHNHSAYALI ERDKRRAG