GCL2_ARATH
ID GCL2_ARATH Reviewed; 405 AA.
AC Q8VZQ6; Q9SKU0;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=LanC-like protein GCL2;
DE AltName: Full=G protein-coupled receptor 2-like protein 2;
DE Short=Protein GCR2-like 2;
GN Name=GCL2; OrderedLocusNames=At2g20770; ORFNames=F5H14.26;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=18714360; DOI=10.1371/journal.pone.0002982;
RA Guo J., Zeng Q., Emami M., Ellis B.E., Chen J.G.;
RT "The GCR2 gene family is not required for ABA control of seed germination
RT and early seedling development in Arabidopsis.";
RL PLoS ONE 3:E2982-E2982(2008).
CC -!- FUNCTION: May play a role in signaling. May be not involved in abscisic
CC acid (ABA) signaling. {ECO:0000269|PubMed:18714360}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:18714360}.
CC -!- SIMILARITY: Belongs to the LanC-like protein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD20918.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006234; AAD20918.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07068.1; -; Genomic_DNA.
DR EMBL; AY063934; AAL36290.1; -; mRNA.
DR EMBL; AY096480; AAM20120.1; -; mRNA.
DR PIR; B84593; B84593.
DR RefSeq; NP_850003.1; NM_179672.4.
DR AlphaFoldDB; Q8VZQ6; -.
DR SMR; Q8VZQ6; -.
DR STRING; 3702.AT2G20770.1; -.
DR iPTMnet; Q8VZQ6; -.
DR PaxDb; Q8VZQ6; -.
DR PRIDE; Q8VZQ6; -.
DR ProteomicsDB; 221951; -.
DR EnsemblPlants; AT2G20770.1; AT2G20770.1; AT2G20770.
DR GeneID; 816606; -.
DR Gramene; AT2G20770.1; AT2G20770.1; AT2G20770.
DR KEGG; ath:AT2G20770; -.
DR Araport; AT2G20770; -.
DR TAIR; locus:2051449; AT2G20770.
DR eggNOG; KOG2787; Eukaryota.
DR HOGENOM; CLU_036244_0_1_1; -.
DR InParanoid; Q8VZQ6; -.
DR OMA; YSLVFIN; -.
DR OrthoDB; 681208at2759; -.
DR PhylomeDB; Q8VZQ6; -.
DR PRO; PR:Q8VZQ6; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8VZQ6; baseline and differential.
DR Genevisible; Q8VZQ6; AT.
DR GO; GO:0019898; C:extrinsic component of membrane; ISS:TAIR.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR007822; LANC-like.
DR InterPro; IPR020464; LanC-like_prot_euk.
DR Pfam; PF05147; LANC_like; 1.
DR PRINTS; PR01951; LANCEUKARYTE.
DR PRINTS; PR01950; LANCSUPER.
DR SMART; SM01260; LANC_like; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..405
FT /note="LanC-like protein GCL2"
FT /id="PRO_0000424629"
FT BINDING 278
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 323
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 324
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 405 AA; 44490 MW; 90C431748B89A186 CRC64;
MAGRFFDNVM PDFVKEKESV SGGDTLRNLL AMPYSSLSQQ LKRSALDLKE TVVIETWGFS
GQTVEDFTLY SGTLGAAFLL FRAYQVTGNA NDLSLCLEIV KACDTASASS GDVTFLCGRA
GVCGLGAVAA KLSGEEDLLN YYLGQFRLIR LSSDLPNELL YGRVGYLWAC LFINKYIGKE
TLSSDTIREV AQEIIKEGRS MAKKGSSPLM FEWYGKRYWG AAHGLAGIMH VLMDVQLKPD
EAEDVKGTLK YMIKNRFPSG NYPASEEDKK KDILVHWCHG APGIALTLGK AAEVFGEREF
LEASAAAAEV VWNRGLLKRV GICHGISGNA YVFLALYRAT GRSEYLYRAK AFASFLLDRG
PKLLSKGEMH GGDSPYSLFE GVAGMAYLFL DMVDPSEARF PGYEL
