GCM1_RAT
ID GCM1_RAT Reviewed; 436 AA.
AC Q9Z288;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Chorion-specific transcription factor GCMa;
DE AltName: Full=GCM motif protein 1;
DE AltName: Full=Glial cells missing homolog 1;
GN Name=Gcm1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9770492; DOI=10.1073/pnas.95.21.12364;
RA Kim J., Jones B.W., Zock C., Chen Z., Wang H., Goodman C.S., Anderson D.J.;
RT "Isolation and characterization of mammalian homologs of the Drosophila
RT gene glial cells missing.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:12364-12369(1998).
CC -!- FUNCTION: Transcription factor involved in the control of expression of
CC placental growth factor (PGF) and other placenta-specific genes. Binds
CC to the trophoblast-specific element 2 (TSE2) of the aromatase gene
CC enhancer. Binds to the SYDE1 promoter. Has a central role in mediating
CC the differentiation of trophoblast cells along both the villous and
CC extravillous pathways in placental development.
CC {ECO:0000250|UniProtKB:Q9NP62}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00245}.
CC -!- PTM: Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).
CC {ECO:0000250}.
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DR EMBL; AF081557; AAC64783.1; -; mRNA.
DR RefSeq; NP_058882.1; NM_017186.2.
DR AlphaFoldDB; Q9Z288; -.
DR SMR; Q9Z288; -.
DR STRING; 10116.ENSRNOP00000010583; -.
DR iPTMnet; Q9Z288; -.
DR PhosphoSitePlus; Q9Z288; -.
DR PaxDb; Q9Z288; -.
DR PRIDE; Q9Z288; -.
DR Ensembl; ENSRNOT00000010583; ENSRNOP00000010583; ENSRNOG00000007932.
DR GeneID; 29394; -.
DR KEGG; rno:29394; -.
DR UCSC; RGD:61852; rat.
DR CTD; 8521; -.
DR RGD; 61852; Gcm1.
DR eggNOG; ENOG502QWH2; Eukaryota.
DR GeneTree; ENSGT00390000006777; -.
DR HOGENOM; CLU_043105_0_0_1; -.
DR InParanoid; Q9Z288; -.
DR OMA; FPLTNWP; -.
DR OrthoDB; 396012at2759; -.
DR PhylomeDB; Q9Z288; -.
DR TreeFam; TF324146; -.
DR PRO; PR:Q9Z288; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000007932; Expressed in kidney and 2 other tissues.
DR Genevisible; Q9Z288; RN.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0042826; F:histone deacetylase binding; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0008270; F:zinc ion binding; ISO:RGD.
DR GO; GO:0060018; P:astrocyte fate commitment; ISO:RGD.
DR GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; ISO:RGD.
DR GO; GO:0060706; P:cell differentiation involved in embryonic placenta development; ISO:RGD.
DR GO; GO:0042063; P:gliogenesis; IBA:GO_Central.
DR GO; GO:0060143; P:positive regulation of syncytium formation by plasma membrane fusion; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0060800; P:regulation of cell differentiation involved in embryonic placenta development; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0000768; P:syncytium formation by plasma membrane fusion; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISO:RGD.
DR Gene3D; 2.20.25.670; -; 1.
DR Gene3D; 3.30.70.3530; -; 1.
DR InterPro; IPR039791; GCM.
DR InterPro; IPR036115; GCM_dom_sf.
DR InterPro; IPR043020; GCM_large.
DR InterPro; IPR043021; GCM_small.
DR InterPro; IPR003902; Tscrpt_reg_GCM.
DR PANTHER; PTHR12414; PTHR12414; 1.
DR Pfam; PF03615; GCM; 1.
DR SUPFAM; SSF90073; SSF90073; 1.
DR PROSITE; PS50807; GCM; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc.
FT CHAIN 1..436
FT /note="Chorion-specific transcription factor GCMa"
FT /id="PRO_0000126649"
FT DNA_BIND 14..169
FT /note="GCM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00245"
FT BINDING 76
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00245"
FT BINDING 82
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00245"
FT BINDING 86
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00245"
FT BINDING 113
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00245"
FT BINDING 116
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00245"
FT BINDING 125
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00245"
FT BINDING 152
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00245"
FT BINDING 154
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00245"
SQ SEQUENCE 436 AA; 49522 MW; 042089C09BDCEC52 CRC64;
MELDDFDPED KEILSWDIND MKLPQNVKKT DWFQEWPDSY VKHIYSSDDR SAQRHLSSWA
MRNTNNHNSR ILKKSCLGVV VCSRDCSTEE GRKIYLRPAI CDKARQKQQR KSCPNCNGPL
KLIPCRGHGG FPVTNFWRHD GRFIFFQSKG EHDHPRPETK LEAEARRAMK KVHMASASSS
LRMKGRPEMK GLPGEIPSQG SLPLTWSFQE GVQLPSGYST PLIANAPQQN SLNDCLSFPK
SYDLGGTTEL EDPTSTLDPT KLYERYKFSS SKVYSAEDQF QPPVPGVYGD YDEAQTWNKN
AVLGRSPTDD TYYPPYPLPV ASWPCDYLPS QSSLEHSPQQ VPLEPPAAQP GHHPLWTNPG
GEPYEEKVPV DFSSYVPSVT YHSPQQDPFL LAYGSHPQQQ YALPGKSNRW DFDEEMACMG
LDHFNNEMLL NLCSLK
