GCNFA_DANRE
ID GCNFA_DANRE Reviewed; 477 AA.
AC Q9PU65;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Nuclear receptor subfamily 6 group A member 1-A;
DE AltName: Full=Germ cell nuclear factor A;
DE Short=GCNF-A;
DE Short=zfGCNF;
GN Name=nr6a1a {ECO:0000312|ZFIN:ZDB-GENE-991207-19};
GN Synonyms=gcnf {ECO:0000303|PubMed:10398411};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAB58352.2}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis {ECO:0000312|EMBL:CAB58352.2};
RX PubMed=10398411;
RX DOI=10.1002/(sici)1098-2795(199908)53:4<369::aid-mrd1>3.0.co;2-u;
RA Braat A.K., Zandbergen M.A., De Vries E., Van Der Burg B., Bogerd J.,
RA Goos H.J.T.;
RT "Cloning and expression of the zebrafish germ cell nuclear factor.";
RL Mol. Reprod. Dev. 53:369-375(1999).
RN [2] {ECO:0000305, ECO:0000312|EMBL:CAB58352.2}
RP SEQUENCE REVISION TO N-TERMINUS; 235 AND 236.
RA Bogerd J.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable orphan nuclear receptor. Binds to a response element
CC containing repeats of the motif 5'-AGGTCA-3' (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P70033}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in germ cells, being predominant in
CC previtellogenic oocytes in the ovary and in spermatocytes in the
CC testis. {ECO:0000269|PubMed:10398411}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR6
CC subfamily. {ECO:0000255}.
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DR EMBL; AJ007703; CAB58352.2; -; mRNA.
DR RefSeq; NP_571331.2; NM_131256.2.
DR AlphaFoldDB; Q9PU65; -.
DR SMR; Q9PU65; -.
DR STRING; 7955.ENSDARP00000105986; -.
DR PaxDb; Q9PU65; -.
DR GeneID; 30506; -.
DR KEGG; dre:30506; -.
DR CTD; 30506; -.
DR ZFIN; ZDB-GENE-991207-19; nr6a1a.
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; Q9PU65; -.
DR OrthoDB; 619653at2759; -.
DR PhylomeDB; Q9PU65; -.
DR Reactome; R-DRE-383280; Nuclear Receptor transcription pathway.
DR PRO; PR:Q9PU65; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; ISS:UniProtKB.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR GO; GO:0030917; P:midbrain-hindbrain boundary development; ISS:UniProtKB.
DR GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..477
FT /note="Nuclear receptor subfamily 6 group A member 1-A"
FT /id="PRO_0000292604"
FT DOMAIN 230..461
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 40..115
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 43..63
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 79..98
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 147..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 54056 MW; CEE6F19F611DC96C CRC64;
MVDKTHETEF SKKQLEASSS GHGGVLIDAE ENGIHDQAEQ RSCLICGDRA TGLHYGIISC
EGCKGFFKRS ICNKRVYRCS RDKNCEMSRK QRNRCQYCRL LKCLQMGMNR KAIREDGMPG
GRNKSIGPVQ ISDEEIERIM SGQEFKDEAN MPEHTWGNNG DSDHSSPGNG VSDGNQPSPV
STLSSNRSVE LNGYTTALRE QYIGNAMAQH YQFLPHLFGY AAQPRSLYPQ SHTLIGQLVA
AEDLAPLGTP MLIEDGYRVT QVELFALLCR LADELLFRQI SWIKKLPFFC DLSIEDYTRL
LSATWQELIL LACLTVYSAQ VLGDLANVTH KYTPSDDELH SFSEDGMEVM EKLIYLFRKF
HQLKVSNEEY ACMKAINFLN QDIRGLTNVT QLEQLNKRYW YVCQDYTEYK YPHQPKRFPE
IMMCLPEIRC IAGKLVNIPL EQLPLLFKAV LHSCKSSLSS YRTSSSPCVT KGTAPAN
