GCNFB_DANRE
ID GCNFB_DANRE Reviewed; 455 AA.
AC Q4V8R7; Q7T003;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Nuclear receptor subfamily 6 group A member 1-B;
DE AltName: Full=Germ cell nuclear factor B;
DE Short=GCNF-B;
GN Name=nr6a1b {ECO:0000312|ZFIN:ZDB-GENE-040724-202};
GN Synonyms=gcnf {ECO:0000250|UniProtKB:P70033};
GN ORFNames=si:ch211-167p9.1, zgc:114189;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000305, ECO:0000312|EMBL:CAE30390.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH97237.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305, ECO:0000312|EMBL:CAE30390.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 35-453.
RA Bertrand S., Sachs L., Bardet P.-L., Bonnelye E., Dufraisse M., Escriva H.,
RA Haramis A.-P., Marchand O., Safi R., Vanacker J.-M., Zelus D., Thisse C.,
RA Thisse B., Laudet V.;
RT "Nuclear receptors expression during zebrafish development reveals an
RT unsuspected link with nervous system and retina development.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable orphan nuclear receptor. Binds to a response element
CC containing repeats of the motif 5'-AGGTCA-3' (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P70033}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR6
CC subfamily. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAE30390.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL772368; CAE30390.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC097237; AAH97237.1; -; mRNA.
DR EMBL; DQ017610; AAY85265.1; -; mRNA.
DR RefSeq; NP_001028892.1; NM_001033720.1.
DR AlphaFoldDB; Q4V8R7; -.
DR SMR; Q4V8R7; -.
DR STRING; 7955.ENSDARP00000109637; -.
DR PaxDb; Q4V8R7; -.
DR GeneID; 497167; -.
DR KEGG; dre:497167; -.
DR CTD; 497167; -.
DR ZFIN; ZDB-GENE-040724-202; nr6a1b.
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; Q4V8R7; -.
DR OrthoDB; 619653at2759; -.
DR PhylomeDB; Q4V8R7; -.
DR PRO; PR:Q4V8R7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; ISS:UniProtKB.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR GO; GO:0030917; P:midbrain-hindbrain boundary development; ISS:UniProtKB.
DR GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..455
FT /note="Nuclear receptor subfamily 6 group A member 1-B"
FT /id="PRO_0000292605"
FT DOMAIN 215..446
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 38..113
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 41..61
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 77..96
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 145..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 52019 MW; 2298B7A8411E09EF CRC64;
MEVENRPNTY DFSKRDKLLS NRFYEENSLQ DETDDGGERW CLICGDRASG LHYGIISCEG
CKGFFKRSIC NKRIYRCNRD KNCQMSRKQR NRCQYCRLQK CLQMGMNRKA IREDGMPGGR
NKMIGPVHIS LEEIERLMSG QEFKEGSDLS DSWSHGYSNH SSPGNSLSEG GQSLSFSSSR
SVSCRDECIS PQLTHTFLMC KYPLPPPTGS ILKTQTHTLT GQILADEDLT PLTTPMLIED
GYSVTQSELL ALLCGIADEL LFRQIVWLKR LPFFTDLSIK DCTRLLGSSW HQLILLSSIT
VHSAQILGEL ANVTHHYTPS SHTLQRFGED AMEVMESLNF LFRKFHQLNI SNEEYSCLKT
ITLLNQETTG LCNTSMLKQL SERYWTLCRE LTERLHPQRP KRFSDIITCL TEIRHTSGKM
MSIPLEQLPL LFKAVLYSCT TNQNPWLPKS STSRT
