ID   GCP2_PONAB              Reviewed;         902 AA.
AC   Q5R5J6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Gamma-tubulin complex component 2;
DE            Short=GCP-2;
GN   Name=TUBGCP2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation
CC       at the centrosome. Plays a role in neuronal migration.
CC       {ECO:0000250|UniProtKB:Q9BSJ2}.
CC   -!- SUBUNIT: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2,
CC       TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with ATF5; the
CC       ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother
CC       centriole and the pericentriolar material (PCM) in the centrosome.
CC       {ECO:0000250|UniProtKB:Q9BSJ2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q9BSJ2}.
CC   -!- SIMILARITY: Belongs to the TUBGCP family. {ECO:0000305}.
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DR   EMBL; CR860862; CAH92970.1; -; mRNA.
DR   RefSeq; NP_001126754.1; NM_001133282.1.
DR   AlphaFoldDB; Q5R5J6; -.
DR   SMR; Q5R5J6; -.
DR   STRING; 9601.ENSPPYP00000003257; -.
DR   PRIDE; Q5R5J6; -.
DR   GeneID; 100173756; -.
DR   KEGG; pon:100173756; -.
DR   CTD; 10844; -.
DR   eggNOG; KOG2001; Eukaryota.
DR   InParanoid; Q5R5J6; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:UniProt.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
DR   GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR   GO; GO:0001764; P:neuron migration; ISS:UniProtKB.
DR   Gene3D; 1.20.120.1900; -; 1.
DR   InterPro; IPR007259; GCP.
DR   InterPro; IPR040457; GCP_C.
DR   InterPro; IPR042241; GCP_C_sf.
DR   InterPro; IPR041470; GCP_N.
DR   PANTHER; PTHR19302; PTHR19302; 1.
DR   Pfam; PF04130; GCP_C_terminal; 1.
DR   Pfam; PF17681; GCP_N_terminal; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Reference proteome.
FT   CHAIN           1..902
FT                   /note="Gamma-tubulin complex component 2"
FT                   /id="PRO_0000301686"
FT   REGION          875..902
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         83
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSJ2"
SQ   SEQUENCE   902 AA;  102469 MW;  0859F2751601B2E6 CRC64;
     MSEFRIHHDV NELLSLLRVH GGDGAEVYID LLQKNRTPYV TTTVSAHSAK VKIAEFSRTP
     EDFLKKYDEL KSKNTRNLDP LVYLLSKLTE DKETLQYLQQ NAKERAELAA AAVGSSTTSV
     NVPAAASKIS MQELEELRKQ LGSVATGSTL QQSLELKRKM LRDKQNKKNS DQHLPIFPAW
     VYERPALIGD FLIGAGISTD TALPIGTLPL ASQESAVVED LLYVLVGVDG RYVTAQPLAG
     RQSRTFLVDP NLDLSIRELV NRILPVAASY STVTRFIEEK SSFEYGQVNH ALAAAMRTLV
     KEHLILVSQL EQLHRQGLLS LQKLWFYIQP AMRTMDILAS LATSVDKGEC LGGSTLSLLH
     DRSFSYTGDS QAQELCLYLT KAASAPYFEV LEKWIYRGII HDPYSEFMVE EHELRKERIQ
     EDYNDKYWDQ RYTIVQQQIP SFLQKMADKI LSTGKYLNVV RECGHDVTCP VAKEIIYTLK
     ERAYVEQIEK AFNYASKVLL DFLMEEKELV AHLRSIKRYF LMDQGDFFVH FMDLAEEELR
     KPVEDITPPR LEALLELALR MSTANTDPFK DDLKIDLMPH DLITQLLRVL AIETKQEKAM
     AHADPTELTL SGLEAFSFDY IVKWPLSLII NRKALTRYQM LFRHMFYCKH VERQLCSVWI
     SNKTAKQHSL PSAQWFAGAF TLRQRMLNFV QNIQYYMMFE VMEPTWHILE KNLKSASNID
     DVLGYHTGFL DTCLKDCMLT NPELLKVFSK LMSVCVMFTN CMQKFTQSMK LDGELGGQTL
     EHGTLPGLPA GAEDRARKEL ARKHLAEHAD AAQLVSGFEA TINKFDKNFS AHLLDLLARL
     SIYSTSDCEH GMASVTSRLD FNGFYTERLE RLSAERSQKA APQVPVLRGP PAPAPRVAVT
     AQ