ID   GCP3_XENLA              Reviewed;         906 AA.
AC   O73787;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Gamma-tubulin complex component 3 homolog;
DE   AltName: Full=Gamma-ring complex protein 109;
DE   AltName: Full=Xgrip109;
DE            Short=x109p;
GN   Name=tubgcp3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Oocyte;
RX   PubMed=9566968; DOI=10.1083/jcb.141.3.675;
RA   Martin O.C., Gunawardane R.N., Iwamatsu A., Zheng Y.;
RT   "Xgrip109: a gamma tubulin-associated protein with an essential role in
RT   gamma tubulin ring complex (gammaTuRC) assembly and centrosome function.";
RL   J. Cell Biol. 141:675-687(1998).
CC   -!- FUNCTION: Necessary for the recruitment of gamma-tubulin to the
CC       centrosome and for the formation of a functional centrosome.
CC   -!- SUBUNIT: Interacts with gamma-tubulin.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome.
CC   -!- SIMILARITY: Belongs to the TUBGCP family. {ECO:0000305}.
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DR   EMBL; AF052663; AAC06304.1; -; mRNA.
DR   PDB; 6TF9; EM; 4.80 A; QP1/cP1/dP1/eP1/fP1=1-906.
DR   PDBsum; 6TF9; -.
DR   AlphaFoldDB; O73787; -.
DR   SMR; O73787; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005813; C:centrosome; IEA:UniProt.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR   Gene3D; 1.20.120.1900; -; 1.
DR   InterPro; IPR007259; GCP.
DR   InterPro; IPR040457; GCP_C.
DR   InterPro; IPR042241; GCP_C_sf.
DR   InterPro; IPR041470; GCP_N.
DR   PANTHER; PTHR19302; PTHR19302; 1.
DR   Pfam; PF04130; GCP_C_terminal; 1.
DR   Pfam; PF17681; GCP_N_terminal; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Cytoskeleton; Direct protein sequencing;
KW   Microtubule; Reference proteome.
FT   CHAIN           1..906
FT                   /note="Gamma-tubulin complex component 3 homolog"
FT                   /id="PRO_0000078120"
FT   REGION          208..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..229
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   906 AA;  103653 MW;  AEF790ADBED68D65 CRC64;
     MAVPDQKSPN VLLQNLCCRI LGKGEADVAQ QFQYAVRVIG SNFAPTVERD EFLVTEKIKK
     EFVRQRREAD GALFSELHRK LQSQGVLKNR WSILYLLLSL SEDPRKQPNK TSSFAALFAQ
     ALPRDAHSTP YYYARPQSLP LSYQDRNVQC AQNAASIGSS GISSIGMYAL NGPTPQSIIQ
     GQSNQTPNMG DALRQQLGSR LAWTLAAGQQ PSQQSTTTKG LPNTVSRNVP RTRREGDSSG
     SVEITETSLV RDLLYVFQGI DGKFVKMCNS ENCYKVDGKV AVSKSLKDIT SKLSELGWLH
     NKIKKYTDQR SLDRAFGLVG QSFCAALHQE LKEYYRLLSV LHSQLQVEDD QGVNLGVESS
     LTLRRLLVWT FDPKIRLKTL AALVDHCQGR KGGELASAVH AYTKTGDPYM RSLVQHILGL
     VAYPILNFLY RWIYDGELED TYHEFFVASD PVVKTDRLWH DKYSLRKSMI PSFMTMDQSR
     KVLLIGKSIN FLHQVCHDQT PASKAMAVGK SAESPKDAAE LFTDLENAFQ TKIDAAYFDT
     SKYLLDVLNK NYNLLEHMQA MRRYLLLGQG DFIRHLMDLL KPELVRPATT LYQHNLTGIL
     ETAVRATNAQ FDNPEILKRL DVRLLEVSPG DTGWDVFSLD YHVDGPIATV FTRECMSHYL
     RVFNFLWRAK RMEYILTDIW KGHMCNAKLL KGMPELSGVL HQCHILASEM VHFIHQMQYY
     ITFEVLECSW DELWNKVLKA QDLDHIIAAH DVFLDTIISR CLLDSESRAL LNQLRAVFDQ
     IIEFQNAQDA LYRAALEELQ QRLQFEERKK ERESEGEWGV TAAEEDVENK RIQEFQESIP
     KMRSQLRILT HFYQGIVQQF LVLLTTSTDE SLRFLSFRLD FNEHYKAREP RLRVSMGTRG
     RRSFHV