ID   GCP5_MACFA              Reviewed;         725 AA.
AC   Q95K09;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2002, sequence version 2.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Gamma-tubulin complex component 5;
DE            Short=GCP-5;
DE   Flags: Fragment;
GN   Name=TUBGCP5; Synonyms=GCP5; ORFNames=QtsA-11379;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation
CC       at the centrosome. {ECO:0000250}.
CC   -!- SUBUNIT: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2,
CC       TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TUBGCP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB62963.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB070018; BAB62963.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q95K09; -.
DR   SMR; Q95K09; -.
DR   STRING; 9541.XP_005558962.1; -.
DR   eggNOG; KOG4344; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:UniProt.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0000931; C:gamma-tubulin large complex; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0007020; P:microtubule nucleation; ISS:UniProtKB.
DR   Gene3D; 1.20.120.1900; -; 1.
DR   InterPro; IPR007259; GCP.
DR   InterPro; IPR040457; GCP_C.
DR   InterPro; IPR042241; GCP_C_sf.
DR   InterPro; IPR041470; GCP_N.
DR   PANTHER; PTHR19302; PTHR19302; 1.
DR   Pfam; PF04130; GCP_C_terminal; 1.
DR   Pfam; PF17681; GCP_N_terminal; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   CHAIN           <1..725
FT                   /note="Gamma-tubulin complex component 5"
FT                   /id="PRO_0000078130"
FT   REGION          222..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   725 AA;  83321 MW;  62098FB0195E0AB7 CRC64;
     IIVTHLTHSC LRSVLEQIAA YGQVVFRLQQ FIDEVMGHSS ESMLPGSGSV PKKSTEAPFR
     TYQAFMWALY KYFISSKEEL AEIEKCIINN DATITLAIVV DKLAPRLAQL KVLHKVFSTG
     VAEVPPDTRN VVRASHLLNT LYKAILEYDD VGEASEQTVS LLFSLWVETV RPYLQTVDEW
     IVHGHLWDGA REFIIQRNKN VPVNHRDFWY ATYTLYSVSE KTENEEKMSD NASASSGSDQ
     GPSSRQHTMV SFLKPVLKQI IMAGKSMQLL KNLQCAESTT CQAGARDAER KSLYTLFLES
     VQSRLRHGED STPQVLTEQQ ATKENLMKMQ SIAERHLELD DVHDPLLAIN FARMYLEQSD
     FHEKFAGGDV CVDRSSESVT CQTFELTLRS CLYPHIDKQY LDCCGNLMQT LKKDYRLVEY
     LQAMRNFFLM EGGDTMYDFY TSIFDKIREK ETWQNVSFLN VQLQEAVGQR YPEDSSRLSI
     SFENVDTAKK KLPVHILDGL TLSYKVPWPV DIVISLECQK IYNQVFLLLL QIKWAKYSLD
     VLLFGELVST AEKPRLQEGL VREQDTVAQF GPQKEPVRQQ IHRMFLLRVK LMHFVNSLHN
     YIMTRILHST GLEFQHQVEE AKDLDQLIKI HYRYLSTIHD RCLLREKVSF VKEAIMKVLN
     LALMFADGWQ AGLGTWRMES IEKMESDFKN CHMFLVTILN KAVCRGSFPH LESLALSLMA
     GMEQS