GCP6_HUMAN
ID GCP6_HUMAN Reviewed; 1819 AA.
AC Q96RT7; Q5JZ80; Q6PJ40; Q86YE9; Q9BY91; Q9UGX3; Q9UGX4;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 3.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Gamma-tubulin complex component 6;
DE Short=GCP-6;
GN Name=TUBGCP6; Synonyms=GCP6, KIAA1669;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, SUBCELLULAR
RP LOCATION, AND VARIANTS SER-567 AND ALA-1377.
RX PubMed=11694571; DOI=10.1091/mbc.12.11.3340;
RA Murphy S.M., Preble A.M., Patel U.K., O'Connell K.L., Dias D.P., Moritz M.,
RA Agard D., Stults J.T., Stearns T.;
RT "GCP5 and GCP6: two new members of the human gamma-tubulin complex.";
RL Mol. Biol. Cell 12:3340-3352(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-1819 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=11258795; DOI=10.1093/dnares/8.1.1;
RA Hirosawa M., Nagase T., Murahashi Y., Kikuno R., Ohara O.;
RT "Identification of novel transcribed sequences on human chromosome 22 by
RT expressed sequence tag mapping.";
RL DNA Res. 8:1-9(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 811-1819 (ISOFORM 1), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1315-1819 (ISOFORM 3), AND VARIANT LEU-1621.
RC TISSUE=Brain, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Lymphoblast;
RX PubMed=14654843; DOI=10.1038/nature02166;
RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.;
RT "Proteomic characterization of the human centrosome by protein correlation
RT profiling.";
RL Nature 426:570-574(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP INVOLVEMENT IN MCCRP1.
RX PubMed=22279524; DOI=10.1371/journal.pone.0028936;
RA Puffenberger E.G., Jinks R.N., Sougnez C., Cibulskis K., Willert R.A.,
RA Achilly N.P., Cassidy R.P., Fiorentini C.J., Heiken K.F., Lawrence J.J.,
RA Mahoney M.H., Miller C.J., Nair D.T., Politi K.A., Worcester K.N.,
RA Setton R.A., Dipiazza R., Sherman E.A., Eastman J.T., Francklyn C.,
RA Robey-Bond S., Rider N.L., Gabriel S., Morton D.H., Strauss K.A.;
RT "Genetic mapping and exome sequencing identify variants associated with
RT five novel diseases.";
RL PLoS ONE 7:E28936-E28936(2012).
CC -!- FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation
CC at the centrosome. {ECO:0000269|PubMed:11694571}.
CC -!- SUBUNIT: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2,
CC TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. {ECO:0000269|PubMed:11694571}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:11694571,
CC ECO:0000269|PubMed:14654843}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96RT7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96RT7-2; Sequence=VSP_001624;
CC Name=3;
CC IsoId=Q96RT7-3; Sequence=VSP_017208, VSP_017209;
CC -!- DISEASE: Microcephaly and chorioretinopathy, autosomal recessive, 1
CC (MCCRP1) [MIM:251270]: A syndrome characterized by microcephaly,
CC cognitive impairment, underdeveloped retina and choroid, and epilepsy
CC in some patients. The more anterior parts of the retina, near the
CC periphery and pars plana, have a grayish hue and diminutive vasculature
CC similar to retinopathy of prematurity. Visual impairment becomes
CC evident during the first year of life. {ECO:0000269|PubMed:22279524}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SIMILARITY: Belongs to the TUBGCP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH42165.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB33339.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AF272887; AAK82968.1; -; mRNA.
DR EMBL; AL022328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB051456; BAB33339.1; ALT_SEQ; mRNA.
DR EMBL; BC023573; AAH23573.1; -; mRNA.
DR EMBL; BC042165; AAH42165.1; ALT_FRAME; mRNA.
DR CCDS; CCDS14087.1; -. [Q96RT7-1]
DR RefSeq; NP_065194.2; NM_020461.3. [Q96RT7-1]
DR PDB; 6M33; X-ray; 3.29 A; A=1-119.
DR PDB; 6V6C; EM; 4.50 A; L=1-1819.
DR PDB; 6V6S; EM; 4.30 A; L=1-1819.
DR PDB; 6X0U; EM; 3.60 A; D=1-1819.
DR PDB; 7AS4; EM; 4.13 A; 4/L=1-1819.
DR PDB; 7QJ0; EM; 5.32 A; L=1-1819.
DR PDB; 7QJ1; EM; 7.00 A; L=1-1819.
DR PDB; 7QJ2; EM; 8.60 A; L=1-1819.
DR PDB; 7QJ3; EM; 7.60 A; L=1-1819.
DR PDB; 7QJ4; EM; 9.00 A; L=1-1819.
DR PDB; 7QJ5; EM; 8.70 A; L/c=1-1819.
DR PDB; 7QJ6; EM; 7.80 A; L/c=1-1819.
DR PDB; 7QJ7; EM; 8.70 A; L/c=1-1819.
DR PDB; 7QJ8; EM; 8.70 A; L/c=1-1819.
DR PDB; 7QJ9; EM; 8.10 A; L/c=1-1819.
DR PDB; 7QJA; EM; 9.20 A; L/c=1-1819.
DR PDB; 7QJB; EM; 9.20 A; L/c=1-1819.
DR PDB; 7QJC; EM; 16.10 A; L/c=1-1819.
DR PDB; 7QJD; EM; 7.10 A; L/c=1-1819.
DR PDB; 7QJE; EM; 7.80 A; L=1-1819.
DR PDBsum; 6M33; -.
DR PDBsum; 6V6C; -.
DR PDBsum; 6V6S; -.
DR PDBsum; 6X0U; -.
DR PDBsum; 7AS4; -.
DR PDBsum; 7QJ0; -.
DR PDBsum; 7QJ1; -.
DR PDBsum; 7QJ2; -.
DR PDBsum; 7QJ3; -.
DR PDBsum; 7QJ4; -.
DR PDBsum; 7QJ5; -.
DR PDBsum; 7QJ6; -.
DR PDBsum; 7QJ7; -.
DR PDBsum; 7QJ8; -.
DR PDBsum; 7QJ9; -.
DR PDBsum; 7QJA; -.
DR PDBsum; 7QJB; -.
DR PDBsum; 7QJC; -.
DR PDBsum; 7QJD; -.
DR PDBsum; 7QJE; -.
DR AlphaFoldDB; Q96RT7; -.
DR SMR; Q96RT7; -.
DR BioGRID; 124505; 75.
DR CORUM; Q96RT7; -.
DR IntAct; Q96RT7; 34.
DR MINT; Q96RT7; -.
DR STRING; 9606.ENSP00000248846; -.
DR GlyGen; Q96RT7; 1 site.
DR iPTMnet; Q96RT7; -.
DR PhosphoSitePlus; Q96RT7; -.
DR BioMuta; TUBGCP6; -.
DR DMDM; 143811395; -.
DR EPD; Q96RT7; -.
DR jPOST; Q96RT7; -.
DR MassIVE; Q96RT7; -.
DR MaxQB; Q96RT7; -.
DR PaxDb; Q96RT7; -.
DR PeptideAtlas; Q96RT7; -.
DR PRIDE; Q96RT7; -.
DR ProteomicsDB; 78029; -. [Q96RT7-1]
DR ProteomicsDB; 78030; -. [Q96RT7-2]
DR ProteomicsDB; 78031; -. [Q96RT7-3]
DR Antibodypedia; 52528; 123 antibodies from 24 providers.
DR Ensembl; ENST00000248846.10; ENSP00000248846.5; ENSG00000128159.12. [Q96RT7-1]
DR GeneID; 85378; -.
DR KEGG; hsa:85378; -.
DR MANE-Select; ENST00000248846.10; ENSP00000248846.5; NM_020461.4; NP_065194.3.
DR UCSC; uc003bkb.2; human. [Q96RT7-1]
DR CTD; 85378; -.
DR DisGeNET; 85378; -.
DR GeneCards; TUBGCP6; -.
DR HGNC; HGNC:18127; TUBGCP6.
DR HPA; ENSG00000128159; Low tissue specificity.
DR MalaCards; TUBGCP6; -.
DR MIM; 251270; phenotype.
DR MIM; 610053; gene.
DR neXtProt; NX_Q96RT7; -.
DR OpenTargets; ENSG00000128159; -.
DR Orphanet; 2518; Autosomal recessive chorioretinopathy-microcephaly syndrome.
DR PharmGKB; PA38507; -.
DR VEuPathDB; HostDB:ENSG00000128159; -.
DR eggNOG; KOG2000; Eukaryota.
DR GeneTree; ENSGT00940000157810; -.
DR HOGENOM; CLU_002518_0_0_1; -.
DR InParanoid; Q96RT7; -.
DR OMA; HIRVGEN; -.
DR OrthoDB; 110079at2759; -.
DR PhylomeDB; Q96RT7; -.
DR TreeFam; TF106321; -.
DR PathwayCommons; Q96RT7; -.
DR Reactome; R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-HSA-380320; Recruitment of NuMA to mitotic centrosomes.
DR SignaLink; Q96RT7; -.
DR SIGNOR; Q96RT7; -.
DR BioGRID-ORCS; 85378; 683 hits in 1079 CRISPR screens.
DR ChiTaRS; TUBGCP6; human.
DR GeneWiki; TUBGCP6; -.
DR GenomeRNAi; 85378; -.
DR Pharos; Q96RT7; Tbio.
DR PRO; PR:Q96RT7; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q96RT7; protein.
DR Bgee; ENSG00000128159; Expressed in right hemisphere of cerebellum and 111 other tissues.
DR ExpressionAtlas; Q96RT7; baseline and differential.
DR Genevisible; Q96RT7; HS.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0000923; C:equatorial microtubule organizing center; IBA:GO_Central.
DR GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR GO; GO:0000931; C:gamma-tubulin large complex; IDA:UniProtKB.
DR GO; GO:0008275; C:gamma-tubulin small complex; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0007020; P:microtubule nucleation; IDA:UniProtKB.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0051225; P:spindle assembly; IBA:GO_Central.
DR Gene3D; 1.20.120.1900; -; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR045818; GCP6_N.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; PTHR19302; 1.
DR Pfam; PF19340; GCP6_N; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cytoplasm; Cytoskeleton; Microtubule;
KW Reference proteome; Repeat.
FT CHAIN 1..1819
FT /note="Gamma-tubulin complex component 6"
FT /id="PRO_0000078131"
FT REPEAT 1027..1053
FT /note="1"
FT REPEAT 1054..1080
FT /note="2"
FT REPEAT 1081..1107
FT /note="3"
FT REPEAT 1108..1134
FT /note="4"
FT REPEAT 1135..1161
FT /note="5"
FT REPEAT 1162..1188
FT /note="6"
FT REPEAT 1189..1215
FT /note="7"
FT REPEAT 1216..1242
FT /note="8"
FT REPEAT 1243..1269
FT /note="9"
FT REGION 810..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 929..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1269
FT /note="9 X 27 AA tandem repeats"
FT REGION 1271..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1296..1311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1380..1396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1652..1662
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017208"
FT VAR_SEQ 1724..1757
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11258795"
FT /id="VSP_001624"
FT VAR_SEQ 1724..1729
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017209"
FT VARIANT 104
FT /note="L -> P (in dbSNP:rs8137873)"
FT /id="VAR_055852"
FT VARIANT 567
FT /note="L -> S (in dbSNP:rs4838865)"
FT /evidence="ECO:0000269|PubMed:11694571"
FT /id="VAR_031594"
FT VARIANT 624
FT /note="I -> M (in dbSNP:rs35573482)"
FT /id="VAR_055853"
FT VARIANT 884
FT /note="A -> V (in dbSNP:rs34455105)"
FT /id="VAR_055854"
FT VARIANT 1232
FT /note="V -> M (in dbSNP:rs17248287)"
FT /id="VAR_055855"
FT VARIANT 1364
FT /note="S -> C (in dbSNP:rs5771107)"
FT /id="VAR_055856"
FT VARIANT 1377
FT /note="T -> A (in dbSNP:rs11703226)"
FT /evidence="ECO:0000269|PubMed:11694571"
FT /id="VAR_055857"
FT VARIANT 1621
FT /note="V -> L (in dbSNP:rs4838864)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055858"
FT HELIX 4..14
FT /evidence="ECO:0007829|PDB:6M33"
FT HELIX 29..48
FT /evidence="ECO:0007829|PDB:6M33"
FT HELIX 67..79
FT /evidence="ECO:0007829|PDB:6M33"
FT HELIX 83..97
FT /evidence="ECO:0007829|PDB:6M33"
FT HELIX 108..116
FT /evidence="ECO:0007829|PDB:6M33"
SQ SEQUENCE 1819 AA; 200498 MW; 265F89F318996157 CRC64;
MASITQLFDD LCEALLPAAK THLGQRSVNR KRAKRSLKKV AYNALFTNLF QDETQQLQPD
MSKLPARNKI LMLSFDLRVG GLGPKADRLE ELVEELEAAP CCPLLEVGSV LDLLVQLAGS
GPPQVLPRKR DYFLNNKHVG RNVPYSGYDC DDLSVFEMDV QSLISREECL CHSMIQETLQ
VMEAAPGTGL PTVGLFSFGD PCGDRFERDT RVSLFGALVH SRTYDMDVRL GLPPVPDNAD
LSGLAIKVPP SVDQWEDEGF QSASNLTPDS QSEPSVTPDV DLWEAALTYE ASKRRCWERV
GCPPGHREEP YLTEAGRDAF DKFCRLHQGE LQLLAGGVLQ APQPVLVKEC ELVKDVLNVL
IGVVSATFSL CQPAQAFVVK RGVHVSGASP ESISSLLSEV AEYGTCYTRL SHFSLQPVLD
SLYSKGLVFQ AFTSGLRRYL QYYRACVLST PPTLSLLTIG FLFKKLGRQL RYLAELCGVG
AVLPGTCGGG PRAAFPTGVK LLSYLYQEAL HNCSNEHYPV LLSLLKTSCE PYTRFIHDWV
YSGVFRDAYG EFMIQVNHEY LSFRDKLYWT HGYVLISKEV EDCVPVFLKH IAHDIYVCGK
TINLLKLCCP RHYLCWSDVP VPRISVIFSL EELKEIEKDC AVYVGRMERV ARHSSVSKEE
KELRMEIAKQ ELIAHAREAA SRVLSALSDR QMSERMALDA RKREQFQRLK EQFVKDQERR
QAARQEELDD DFSYARELRD RERRLKSLEE ELERKARQAL VDHYSKLSAE AARREQKALW
RIQRHRLESA RLRFLLEDEK HIQEMLKAVS EAHQPQEPPD VLLSVHPQVT SPGPEHPEGG
QGCDSGSAEQ HSPAWDGWNR PGLLTPQPLK PLAVGAGGRG LQQAEGARPF SDSLSIGDFL
PVGPGAEPSV QTGMVPLLEV ALQTINLDLP PSAPGEAPAA ASTQPSRPQE YDFSTVLRPA
VATSPAPGPL QAAECSLGSS GLQLWEDSCG KMDACGSASR ETLLPSHPPR RAALEEGSSQ
PTERLFGQVS GGGLPTGDYA SEIAPTRPRW NTHGHVSDAS IRVGENVSDV APTQPRWNTH
GHVSNASISL GESVSDVAPT RPRWNIHGHV SNASIRVGEN VSDVAPTRPR WNTHGHVSNA
SIRVGENVSD VAPTRPRWNT HGHVSDASIS LGESVSDMAP ARPRWNTHGH VSDASISLGE
SVSDMAPTRP RWNTHGHVSD TSIRVGENVS DVAPIRSRCN THGHVSDASI SLGEPVSDVV
STRPRWNTHV PIPPPHMVLG ALSPEAEPNT PRPQQSPPGH TSQSALSLGA QSTVLDCGPR
LPVEVGPSLS SPSSGCGEGS ISVGENVSDV APTQPWWPNT PGDSVSEELG PGRSGDTEDL
SPNWPLNSQE DTAAQSSPGR GEEAEASAAE AQGGEQAYLA GLAGQYHLER YPDSYESMSE
PPIAHLLRPV LPRAFAFPVD PQVQSAADET AVQLSELLTL PVLMKRSITA PLAAHISLVN
KAAVDYFFVE LHLEAHYEAL RHFLLMEDGE FAQSLSDLLF EKLGAGQTPG ELLNPLVLNS
VLSKALQCSL HGDTPHASNL SLALKYLPEV FAPNAPDVLS CLELRYKVDW PLNIVITEGC
VSKYSGVFSF LLQLKLMMWA LKDVCFHLKR TALLSHMAGS VQFRQLQLFK HEMQHFVKVI
QGYIANQILH VTWCEFRARL ATVGDLEEIQ RAHAEYLHKA VFRGLLTEKA APVMNVIHSI
FSLVLKFRSQ LISQAWGPPG GPRGAEHPNF ALMQQSYNTF KYYSHFLFKV VTKLVNRGYQ
PHLEDFLLRI NFNNYYQDA
