ID   ALLC1_BURMA             Reviewed;         337 AA.
AC   Q62JH0;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Probable allantoicase 1 {ECO:0000255|HAMAP-Rule:MF_00813};
DE            EC=3.5.3.4 {ECO:0000255|HAMAP-Rule:MF_00813};
DE   AltName: Full=Allantoate amidinohydrolase 1 {ECO:0000255|HAMAP-Rule:MF_00813};
GN   Name=alc1 {ECO:0000255|HAMAP-Rule:MF_00813}; OrderedLocusNames=BMA1505;
OS   Burkholderia mallei (strain ATCC 23344).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=243160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23344;
RX   PubMed=15377793; DOI=10.1073/pnas.0403306101;
RA   Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E.,
RA   Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M., Daugherty S.C.,
RA   Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J., Durkin A.S.,
RA   Gwinn M.L., Haft D.H., Khouri H.M., Kolonay J.F., Madupu R., Mohammoud Y.,
RA   Nelson W.C., Radune D., Romero C.M., Sarria S., Selengut J., Shamblin C.,
RA   Sullivan S.A., White O., Yu Y., Zafar N., Zhou L., Fraser C.M.;
RT   "Structural flexibility in the Burkholderia mallei genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC         Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00813};
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC       ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00813}.
CC   -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000255|HAMAP-
CC       Rule:MF_00813}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000010; AAU47713.1; -; Genomic_DNA.
DR   RefSeq; WP_004553942.1; NC_006348.1.
DR   RefSeq; YP_103149.1; NC_006348.1.
DR   AlphaFoldDB; Q62JH0; -.
DR   SMR; Q62JH0; -.
DR   STRING; 243160.BMA1505; -.
DR   EnsemblBacteria; AAU47713; AAU47713; BMA1505.
DR   GeneID; 56595900; -.
DR   KEGG; bma:BMA1505; -.
DR   PATRIC; fig|243160.12.peg.1550; -.
DR   eggNOG; COG4266; Bacteria.
DR   HOGENOM; CLU_038797_1_2_4; -.
DR   OMA; MDDGWET; -.
DR   UniPathway; UPA00395; UER00654.
DR   Proteomes; UP000006693; Chromosome 1.
DR   GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00813; Allantoicase; 1.
DR   InterPro; IPR005164; Allantoicase.
DR   InterPro; IPR015908; Allantoicase_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12045; PTHR12045; 1.
DR   Pfam; PF03561; Allantoicase; 2.
DR   PIRSF; PIRSF016516; Allantoicase; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   TIGRFAMs; TIGR02961; allantoicase; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Purine metabolism.
FT   CHAIN           1..337
FT                   /note="Probable allantoicase 1"
FT                   /id="PRO_0000205917"
SQ   SEQUENCE   337 AA;  37075 MW;  C19FA1DA00478ECF CRC64;
     MALPLSDPNA PEFTRRYVNL ADPRLGAQAL EASDDFFAPK ERMLNPEPAV FIPGKYDDHG
     KWMDGWETRR KRTTGYDWCV VKLARPGVIK GVDIDTSHFT GNFPPAASIE AAHVPDGAPN
     EATKWVEIVP ATTLQGNSHH YVEARDANAY THLRVNLYPD GGIARLRVYG QPQLDWAGAS
     RSALFDLAAM ENGGYVVAAN NQHFGLASNV LLPGRGVNMG DGWETRRRRE PGNDWAIVAL
     AQPGVIRKVE IDTAHFKGNY PDRCSIQAAY VQGGTDSSLV TQAMFWPVLL GEQKLQMDKQ
     HAFEAELAAL GPVTHVRLNI IPDGGVSRLR VWGTLDK