ID   ALLC1_BURPS             Reviewed;         337 AA.
AC   Q63T53;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Probable allantoicase 1 {ECO:0000255|HAMAP-Rule:MF_00813};
DE            EC=3.5.3.4 {ECO:0000255|HAMAP-Rule:MF_00813};
DE   AltName: Full=Allantoate amidinohydrolase 1 {ECO:0000255|HAMAP-Rule:MF_00813};
GN   Name=alc1 {ECO:0000255|HAMAP-Rule:MF_00813}; OrderedLocusNames=BPSL2116;
OS   Burkholderia pseudomallei (strain K96243).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=272560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D.,
RA   Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A.,
RA   Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A.,
RA   Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z.,
RA   Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S.,
RA   Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M.,
RA   Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT   pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC         Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00813};
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC       ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00813}.
CC   -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000255|HAMAP-
CC       Rule:MF_00813}.
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DR   EMBL; BX571965; CAH36119.1; -; Genomic_DNA.
DR   RefSeq; WP_004553942.1; NZ_CP009538.1.
DR   RefSeq; YP_108713.1; NC_006350.1.
DR   AlphaFoldDB; Q63T53; -.
DR   SMR; Q63T53; -.
DR   STRING; 272560.BPSL2116; -.
DR   EnsemblBacteria; CAH36119; CAH36119; BPSL2116.
DR   GeneID; 56595900; -.
DR   KEGG; bps:BPSL2116; -.
DR   PATRIC; fig|272560.51.peg.3351; -.
DR   eggNOG; COG4266; Bacteria.
DR   OMA; MDDGWET; -.
DR   UniPathway; UPA00395; UER00654.
DR   Proteomes; UP000000605; Chromosome 1.
DR   GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00813; Allantoicase; 1.
DR   InterPro; IPR005164; Allantoicase.
DR   InterPro; IPR015908; Allantoicase_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12045; PTHR12045; 1.
DR   Pfam; PF03561; Allantoicase; 2.
DR   PIRSF; PIRSF016516; Allantoicase; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   TIGRFAMs; TIGR02961; allantoicase; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Purine metabolism; Reference proteome.
FT   CHAIN           1..337
FT                   /note="Probable allantoicase 1"
FT                   /id="PRO_0000205919"
SQ   SEQUENCE   337 AA;  37075 MW;  C19FA1DA00478ECF CRC64;
     MALPLSDPNA PEFTRRYVNL ADPRLGAQAL EASDDFFAPK ERMLNPEPAV FIPGKYDDHG
     KWMDGWETRR KRTTGYDWCV VKLARPGVIK GVDIDTSHFT GNFPPAASIE AAHVPDGAPN
     EATKWVEIVP ATTLQGNSHH YVEARDANAY THLRVNLYPD GGIARLRVYG QPQLDWAGAS
     RSALFDLAAM ENGGYVVAAN NQHFGLASNV LLPGRGVNMG DGWETRRRRE PGNDWAIVAL
     AQPGVIRKVE IDTAHFKGNY PDRCSIQAAY VQGGTDSSLV TQAMFWPVLL GEQKLQMDKQ
     HAFEAELAAL GPVTHVRLNI IPDGGVSRLR VWGTLDK