GCS2_SOLUE
ID GCS2_SOLUE Reviewed; 385 AA.
AC Q01ZM2;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Putative glutamate--cysteine ligase 2 {ECO:0000255|HAMAP-Rule:MF_01609};
DE EC=6.3.2.2 {ECO:0000255|HAMAP-Rule:MF_01609};
DE AltName: Full=Gamma-glutamylcysteine synthetase 2 {ECO:0000255|HAMAP-Rule:MF_01609};
DE Short=GCS 2 {ECO:0000255|HAMAP-Rule:MF_01609};
DE Short=Gamma-GCS 2 {ECO:0000255|HAMAP-Rule:MF_01609};
GN OrderedLocusNames=Acid_3926;
OS Solibacter usitatus (strain Ellin6076).
OC Bacteria; Acidobacteria; Bryobacterales; Solibacteraceae;
OC Candidatus Solibacter.
OX NCBI_TaxID=234267;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ellin6076;
RX PubMed=19201974; DOI=10.1128/aem.02294-08;
RA Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT "Three genomes from the phylum Acidobacteria provide insight into the
RT lifestyles of these microorganisms in soils.";
RL Appl. Environ. Microbiol. 75:2046-2056(2009).
CC -!- FUNCTION: ATP-dependent carboxylate-amine ligase which exhibits weak
CC glutamate--cysteine ligase activity. {ECO:0000255|HAMAP-Rule:MF_01609}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-
CC cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01609};
CC -!- SIMILARITY: Belongs to the glutamate--cysteine ligase type 2 family.
CC YbdK subfamily. {ECO:0000255|HAMAP-Rule:MF_01609}.
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DR EMBL; CP000473; ABJ84893.1; -; Genomic_DNA.
DR RefSeq; WP_011685651.1; NC_008536.1.
DR AlphaFoldDB; Q01ZM2; -.
DR SMR; Q01ZM2; -.
DR STRING; 234267.Acid_3926; -.
DR EnsemblBacteria; ABJ84893; ABJ84893; Acid_3926.
DR KEGG; sus:Acid_3926; -.
DR eggNOG; COG2170; Bacteria.
DR HOGENOM; CLU_044848_1_0_0; -.
DR OMA; LIFGLHV; -.
DR OrthoDB; 991285at2; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004357; F:glutamate-cysteine ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0042398; P:cellular modified amino acid biosynthetic process; IEA:InterPro.
DR HAMAP; MF_01609; Glu_cys_ligase_2; 1.
DR InterPro; IPR006336; GCS2.
DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR InterPro; IPR011793; YbdK.
DR Pfam; PF04107; GCS2; 1.
DR SUPFAM; SSF55931; SSF55931; 1.
DR TIGRFAMs; TIGR02050; gshA_cyan_rel; 1.
PE 3: Inferred from homology;
KW ATP-binding; Ligase; Nucleotide-binding.
FT CHAIN 1..385
FT /note="Putative glutamate--cysteine ligase 2"
FT /id="PRO_0000291517"
SQ SEQUENCE 385 AA; 44690 MW; 90BCFC9E689A8FDA CRC64;
MSLMSSVRPS LSIGIEEEYQ TVDPVTRDLR SHIHAEIVQK GKLLLAERVK PEMHQSVVEI
GTGVCQNIQE AKDEIRDIRQ QIIRLARQND LRLAAGGTHP FAQWREQEIY PDDRYRTIVE
DLKMVARANL IFGLHVHIGV EDRETAIQLM NSARYFLPHL LALSANSPFW VGMETGLRSY
RCKVFDKFPR TNIPDLYQSW SEFENYVNLL IHTNCIDNAK KIWWDIRPHP YFPTLEFRIC
DMPMRLEETI AIAALCQAII AKLYRIHEQN LTFRHYSRSL IMENKWRAAR YGLDGKMIDF
GKQTEVPARQ LIEEILEFVS DVVPELGSRE EIAYIRRIME HGNGADRQLR VFHETGDLKK
VVDYMIEETE YGLFAPAFTA AGEGQ