ID   ALLC2_BURMA             Reviewed;         336 AA.
AC   Q62H14;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Probable allantoicase 2 {ECO:0000255|HAMAP-Rule:MF_00813};
DE            EC=3.5.3.4 {ECO:0000255|HAMAP-Rule:MF_00813};
DE   AltName: Full=Allantoate amidinohydrolase 2 {ECO:0000255|HAMAP-Rule:MF_00813};
GN   Name=alc2 {ECO:0000255|HAMAP-Rule:MF_00813}; OrderedLocusNames=BMA2460;
OS   Burkholderia mallei (strain ATCC 23344).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=243160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23344;
RX   PubMed=15377793; DOI=10.1073/pnas.0403306101;
RA   Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E.,
RA   Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M., Daugherty S.C.,
RA   Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J., Durkin A.S.,
RA   Gwinn M.L., Haft D.H., Khouri H.M., Kolonay J.F., Madupu R., Mohammoud Y.,
RA   Nelson W.C., Radune D., Romero C.M., Sarria S., Selengut J., Shamblin C.,
RA   Sullivan S.A., White O., Yu Y., Zafar N., Zhou L., Fraser C.M.;
RT   "Structural flexibility in the Burkholderia mallei genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC         Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00813};
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC       ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00813}.
CC   -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000255|HAMAP-
CC       Rule:MF_00813}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000010; AAU49694.1; -; Genomic_DNA.
DR   RefSeq; WP_004194257.1; NC_006348.1.
DR   RefSeq; YP_104006.1; NC_006348.1.
DR   AlphaFoldDB; Q62H14; -.
DR   SMR; Q62H14; -.
DR   STRING; 243160.BMA2460; -.
DR   EnsemblBacteria; AAU49694; AAU49694; BMA2460.
DR   GeneID; 56593783; -.
DR   KEGG; bma:BMA2460; -.
DR   PATRIC; fig|243160.12.peg.2537; -.
DR   eggNOG; COG4266; Bacteria.
DR   HOGENOM; CLU_038797_1_2_4; -.
DR   OMA; WTHIRIN; -.
DR   UniPathway; UPA00395; UER00654.
DR   Proteomes; UP000006693; Chromosome 1.
DR   GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00813; Allantoicase; 1.
DR   InterPro; IPR005164; Allantoicase.
DR   InterPro; IPR015908; Allantoicase_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12045; PTHR12045; 1.
DR   Pfam; PF03561; Allantoicase; 2.
DR   PIRSF; PIRSF016516; Allantoicase; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   TIGRFAMs; TIGR02961; allantoicase; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Purine metabolism.
FT   CHAIN           1..336
FT                   /note="Probable allantoicase 2"
FT                   /id="PRO_0000205918"
SQ   SEQUENCE   336 AA;  37006 MW;  8433A0EEB79A5D93 CRC64;
     MAAPILDPNA PAFTRRYMNL ADPRLGAKAL FASDEFFAPK ERMLDPEPAV FIPGKYDDHG
     KWMDGWETRR KRTTGHDFCV VRLARPGVVY GVDLDTSHFT GNFPPAASID ACVSDADTPP
     DDAVWETLVP ATTLAGNQHH YVDVSNPRAY THLRVNLYPD GGLARLRVYG QPQRDWSRAA
     RGELVDLAAI ENGAYLVAAN NEHFGPASRM LMPGRGANMG DGWETRRRRE PGNDWAIVAL
     ARPGVIRRVE VDTAHFKGNF PDRCSLQAAR VAGGTDASLV TQAMFWPMLL GEQPLGMDSV
     HTFETQLAAL GPVTHVRLNI HPDGGVSRLR FWGELA