ID   ALLC2_BURPS             Reviewed;         336 AA.
AC   Q63QS9;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Probable allantoicase 2 {ECO:0000255|HAMAP-Rule:MF_00813};
DE            EC=3.5.3.4 {ECO:0000255|HAMAP-Rule:MF_00813};
DE   AltName: Full=Allantoate amidinohydrolase 2 {ECO:0000255|HAMAP-Rule:MF_00813};
GN   Name=alc2 {ECO:0000255|HAMAP-Rule:MF_00813}; OrderedLocusNames=BPSL2945;
OS   Burkholderia pseudomallei (strain K96243).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=272560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D.,
RA   Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A.,
RA   Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A.,
RA   Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z.,
RA   Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S.,
RA   Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M.,
RA   Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT   pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC         Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00813};
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC       ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00813}.
CC   -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000255|HAMAP-
CC       Rule:MF_00813}.
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DR   EMBL; BX571965; CAH36955.1; -; Genomic_DNA.
DR   RefSeq; WP_004531999.1; NZ_CP009538.1.
DR   RefSeq; YP_109539.1; NC_006350.1.
DR   AlphaFoldDB; Q63QS9; -.
DR   SMR; Q63QS9; -.
DR   STRING; 272560.BPSL2945; -.
DR   EnsemblBacteria; CAH36955; CAH36955; BPSL2945.
DR   KEGG; bps:BPSL2945; -.
DR   PATRIC; fig|272560.51.peg.2335; -.
DR   eggNOG; COG4266; Bacteria.
DR   OMA; WTHIRIN; -.
DR   UniPathway; UPA00395; UER00654.
DR   Proteomes; UP000000605; Chromosome 1.
DR   GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00813; Allantoicase; 1.
DR   InterPro; IPR005164; Allantoicase.
DR   InterPro; IPR015908; Allantoicase_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12045; PTHR12045; 1.
DR   Pfam; PF03561; Allantoicase; 2.
DR   PIRSF; PIRSF016516; Allantoicase; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   TIGRFAMs; TIGR02961; allantoicase; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Purine metabolism; Reference proteome.
FT   CHAIN           1..336
FT                   /note="Probable allantoicase 2"
FT                   /id="PRO_0000205920"
SQ   SEQUENCE   336 AA;  36972 MW;  8433A0EEB794BD93 CRC64;
     MAAPILDPNA PAFTRRYMNL ADPRLGAKAL FASDEFFAPK ERMLDPEPAV FIPGKYDDHG
     KWMDGWETRR KRTTGHDFCV VRLARPGVVY GVDLDTSHFT GNFPPAASID ACVSDADTPP
     DDAVWETLVP ATTLAGNQHH YVDVSNPRAY THLRVNLYPD GGLARLRVYG QPQRDWSRAA
     RGELVDLAAI ENGAYLVAAN NEHFGPASRM LMPGRGANMG DGWETRRRRE PGNDWAIVAL
     ARPGVIRRVE VDTAHFKGNF PDRCSLQAAR VAGGTDASLV TQAMFWPMLL GEQPLGMDSV
     HTFETQLAAL GPVTHVRLNI HPDGGVSRLR LWGELA