GCSH2_DICDI
ID GCSH2_DICDI Reviewed; 150 AA.
AC Q54FI0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Glycine cleavage system H-like protein gcvH2;
GN Name=gcvH2; Synonyms=gcvH; ORFNames=DDB_G0290845;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the GcvH family. {ECO:0000305}.
CC -!- CAUTION: Asn-85 is present instead of the conserved Lys which is
CC expected to bind the lipoyl cofactor. {ECO:0000305}.
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DR EMBL; AAFI02000171; EAL62017.1; -; Genomic_DNA.
DR RefSeq; XP_635521.1; XM_630429.1.
DR AlphaFoldDB; Q54FI0; -.
DR SMR; Q54FI0; -.
DR STRING; 44689.DDB0231213; -.
DR PaxDb; Q54FI0; -.
DR EnsemblProtists; EAL62017; EAL62017; DDB_G0290845.
DR GeneID; 8627858; -.
DR KEGG; ddi:DDB_G0290845; -.
DR dictyBase; DDB_G0290845; gcvH2.
DR eggNOG; KOG3373; Eukaryota.
DR HOGENOM; CLU_097408_2_0_1; -.
DR InParanoid; Q54FI0; -.
DR OMA; FARQAWA; -.
DR PhylomeDB; Q54FI0; -.
DR PRO; PR:Q54FI0; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005960; C:glycine cleavage complex; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IBA:GO_Central.
DR GO; GO:0009249; P:protein lipoylation; IBA:GO_Central.
DR CDD; cd06848; GCS_H; 1.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR002930; GCV_H.
DR InterPro; IPR033753; GCV_H/Fam206.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR11715; PTHR11715; 1.
DR Pfam; PF01597; GCV_H; 1.
DR SUPFAM; SSF51230; SSF51230; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..150
FT /note="Glycine cleavage system H-like protein gcvH2"
FT /id="PRO_0000328548"
FT DOMAIN 44..126
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01066"
SQ SEQUENCE 150 AA; 17127 MW; 4E2F2595EB074B62 CRC64;
MNIIKTGIKQ SLVSGIYSKV GIRAFCTHYS AELEWVKLSD DNKVATVGLS SFGAQRLGKI
NYVELPKEHR KCRREEKFGV LESSNATAFG LYAPVSGEVL EVNEKLKKSP SLLNEDPANN
WMVKFKVSKP DEFKKLMDSN KYKKFVQWYR
