ID   GCSH4_DICDI             Reviewed;         209 AA.
AC   Q54JU1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Glycine cleavage system H-like protein gcvH4;
GN   Name=gcvH4; Synonyms=gcvH; ORFNames=DDB_G0287795;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the GcvH family. {ECO:0000305}.
CC   -!- CAUTION: Glu-119 is present instead of the conserved Lys which is
CC       expected to bind the lipoyl cofactor. {ECO:0000305}.
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DR   EMBL; AAFI02000104; EAL63544.1; -; Genomic_DNA.
DR   RefSeq; XP_637061.1; XM_631969.1.
DR   AlphaFoldDB; Q54JU1; -.
DR   SMR; Q54JU1; -.
DR   STRING; 44689.DDB0231219; -.
DR   PaxDb; Q54JU1; -.
DR   EnsemblProtists; EAL63544; EAL63544; DDB_G0287795.
DR   GeneID; 8626315; -.
DR   KEGG; ddi:DDB_G0287795; -.
DR   dictyBase; DDB_G0287795; gcvH4.
DR   eggNOG; KOG3373; Eukaryota.
DR   HOGENOM; CLU_1317542_0_0_1; -.
DR   InParanoid; Q54JU1; -.
DR   OMA; WIKISEN; -.
DR   PRO; PR:Q54JU1; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005960; C:glycine cleavage complex; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IBA:GO_Central.
DR   GO; GO:0009249; P:protein lipoylation; IBA:GO_Central.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR002930; GCV_H.
DR   InterPro; IPR033753; GCV_H/Fam206.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR11715; PTHR11715; 1.
DR   Pfam; PF01597; GCV_H; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..209
FT                   /note="Glycine cleavage system H-like protein gcvH4"
FT                   /id="PRO_0000328550"
FT   DOMAIN          73..159
FT                   /note="Lipoyl-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01066"
FT   REGION          35..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   209 AA;  24667 MW;  8377719903F34012 CRC64;
     MNKIISNKII NNNIIFRNNF NNLFFIRNFI NNKNNNNNNN NNNNNNNNNN NRNKKLKYSP
     NHQWIKISEN KDFATIGITN YVSDIVNNEF NKILKIKLPK INDKIRLNQP FLSIWTKEEE
     NIQFKSPLSG IVSKVNNKFN NQQTTTISTK TTTTTTKIKP KLPLKSNSLF FNNDQDSWTI
     ELKINEPFQT NHLMTEEEYA HYCENTDYK