ID   GCSHL_CHLTB             Reviewed;         117 AA.
AC   B0BBR3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Glycine cleavage system H-like protein {ECO:0000305};
GN   Name=gcsH {ECO:0000312|EMBL:CAP06928.1}; OrderedLocusNames=CTLon_0530;
OS   Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=471473;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCH-1/proctitis;
RX   PubMed=18032721; DOI=10.1101/gr.7020108;
RA   Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA   Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA   Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT   "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT   venereum isolates.";
RL   Genome Res. 18:161-171(2008).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU01066};
CC       Note=Binds 1 lipoyl cofactor covalently. {ECO:0000255|PROSITE-
CC       ProRule:PRU01066};
CC   -!- SIMILARITY: Belongs to the GcvH family. {ECO:0000305}.
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DR   EMBL; AM884177; CAP06928.1; -; Genomic_DNA.
DR   RefSeq; WP_009873697.1; NC_010280.2.
DR   AlphaFoldDB; B0BBR3; -.
DR   SMR; B0BBR3; -.
DR   KEGG; ctl:CTLon_0530; -.
DR   HOGENOM; CLU_097408_2_4_0; -.
DR   OMA; EHEWLSG; -.
DR   Proteomes; UP000000794; Chromosome.
DR   GO; GO:0005960; C:glycine cleavage complex; IEA:InterPro.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:InterPro.
DR   CDD; cd06848; GCS_H; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR002930; GCV_H.
DR   InterPro; IPR033753; GCV_H/Fam206.
DR   InterPro; IPR017514; GcvH_Chlamydia.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR11715; PTHR11715; 1.
DR   Pfam; PF01597; GCV_H; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   TIGRFAMs; TIGR03077; not_gcvH; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
PE   3: Inferred from homology;
KW   Lipoyl.
FT   CHAIN           1..117
FT                   /note="Glycine cleavage system H-like protein"
FT                   /id="PRO_1000114510"
FT   DOMAIN          21..103
FT                   /note="Lipoyl-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01066"
FT   MOD_RES         62
FT                   /note="N6-lipoyllysine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01066"
SQ   SEQUENCE   117 AA;  13147 MW;  4E0720547C0178DF CRC64;
     MKGQKYYSDY HVWIEPIHSR IVKLGLSSQM REHLGNILHI DLPSVGSFIK EGEELCILES
     SKSAIEVLSP VSGEVLEVNT ALEDDILPVN NATESEGWFV VLQLTEDFRS ESFSLEP