ID   GCSHL_CHLTR             Reviewed;         117 AA.
AC   O84284;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Glycine cleavage system H-like protein {ECO:0000305};
GN   Name=gcsH {ECO:0000312|EMBL:AAC67875.1}; OrderedLocusNames=CT_282;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU01066};
CC       Note=Binds 1 lipoyl cofactor covalently. {ECO:0000255|PROSITE-
CC       ProRule:PRU01066};
CC   -!- SIMILARITY: Belongs to the GcvH family. {ECO:0000305}.
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DR   EMBL; AE001273; AAC67875.1; -; Genomic_DNA.
DR   PIR; G71535; G71535.
DR   RefSeq; NP_219787.1; NC_000117.1.
DR   RefSeq; WP_009871629.1; NC_000117.1.
DR   AlphaFoldDB; O84284; -.
DR   SMR; O84284; -.
DR   STRING; 813.O172_01520; -.
DR   EnsemblBacteria; AAC67875; AAC67875; CT_282.
DR   GeneID; 884837; -.
DR   KEGG; ctr:CT_282; -.
DR   PATRIC; fig|272561.5.peg.301; -.
DR   HOGENOM; CLU_097408_2_4_0; -.
DR   InParanoid; O84284; -.
DR   OMA; EHEWLSG; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005960; C:glycine cleavage complex; IEA:InterPro.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IBA:GO_Central.
DR   GO; GO:0009249; P:protein lipoylation; IBA:GO_Central.
DR   CDD; cd06848; GCS_H; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR002930; GCV_H.
DR   InterPro; IPR033753; GCV_H/Fam206.
DR   InterPro; IPR017514; GcvH_Chlamydia.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR11715; PTHR11715; 1.
DR   Pfam; PF01597; GCV_H; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   TIGRFAMs; TIGR03077; not_gcvH; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
PE   3: Inferred from homology;
KW   Lipoyl; Reference proteome.
FT   CHAIN           1..117
FT                   /note="Glycine cleavage system H-like protein"
FT                   /id="PRO_0000166215"
FT   DOMAIN          21..103
FT                   /note="Lipoyl-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01066"
FT   MOD_RES         62
FT                   /note="N6-lipoyllysine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01066"
SQ   SEQUENCE   117 AA;  13144 MW;  10D4D1B704280D0E CRC64;
     MKGKKYYSDY HVWIEPIHSR IVKLGLSSQM REHLGNILHI DLPSLGAFIK EGEKLCILES
     SKSAIEVLSP VSGEVLEVNT ALEDDILPVN NATESEGWFV VLQLTEDFRS ESFSLEP