ID   ALLC_DANRE              Reviewed;         395 AA.
AC   Q6DGA6; Q5TZA9; Q5TZB0;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Allantoicase;
DE            EC=3.5.3.4;
DE   AltName: Full=Allantoate amidinohydrolase;
GN   Name=allc; ORFNames=si:ch211-284k10.3, zgc:91799;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Utilization of purines as secondary nitrogen sources, when
CC       primary sources are limiting. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC         Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC       ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6DGA6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6DGA6-2; Sequence=VSP_029174;
CC   -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH68966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAH68967.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; BX276180; CAH68966.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BX276180; CAH68967.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC076445; AAH76445.1; -; mRNA.
DR   RefSeq; NP_001002716.1; NM_001002716.2. [Q6DGA6-1]
DR   AlphaFoldDB; Q6DGA6; -.
DR   SMR; Q6DGA6; -.
DR   STRING; 7955.ENSDARP00000062428; -.
DR   PaxDb; Q6DGA6; -.
DR   Ensembl; ENSDART00000062429; ENSDARP00000062428; ENSDARG00000042562. [Q6DGA6-1]
DR   GeneID; 436989; -.
DR   KEGG; dre:436989; -.
DR   CTD; 55821; -.
DR   ZFIN; ZDB-GENE-040718-471; allc.
DR   eggNOG; KOG4145; Eukaryota.
DR   GeneTree; ENSGT00390000001793; -.
DR   HOGENOM; CLU_038797_1_2_1; -.
DR   InParanoid; Q6DGA6; -.
DR   OMA; MDDGWET; -.
DR   PhylomeDB; Q6DGA6; -.
DR   TreeFam; TF324677; -.
DR   UniPathway; UPA00395; UER00654.
DR   PRO; PR:Q6DGA6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000042562; Expressed in liver and 12 other tissues.
DR   ExpressionAtlas; Q6DGA6; baseline.
DR   GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00813; Allantoicase; 1.
DR   InterPro; IPR005164; Allantoicase.
DR   InterPro; IPR015908; Allantoicase_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12045; PTHR12045; 1.
DR   Pfam; PF03561; Allantoicase; 2.
DR   PIRSF; PIRSF016516; Allantoicase; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   TIGRFAMs; TIGR02961; allantoicase; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Hydrolase; Purine metabolism; Reference proteome.
FT   CHAIN           1..395
FT                   /note="Allantoicase"
FT                   /id="PRO_0000205909"
FT   VAR_SEQ         78..103
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_029174"
SQ   SEQUENCE   395 AA;  44144 MW;  E7D4B5DBB6D9A0E7 CRC64;
     MAKRQVQKET RSQPHFLQFN NLACETAGGK VIFATDEWFA PARNLLKRDP PEFIASAFTE
     FGKWMDGWET RRKRIPGHDW CIVQLGVPGI IHGFDVDTSF FTGNYAPFAS IQATCLDQMP
     SIALEGDRTG MAASPSQFEA VAQLNSDSWK EVVPVTKLKA GYSDTCHNYL SVSYPHRVTH
     IRFNIYPDGG IARLKVYGIG KKDWSSVFGQ DLVDLVALVN GGVCVGFSDA HYGHPRNMIG
     LGMAENMGDG WETARRLDRP RVLKEDENGI LQVPGSEWAI FRLGHPGIIS KIELDTNHFK
     GNFPDSCRIE ACSLTEDEEN SFIQSQWSSD RSPMWNILLP PQKMKAHHRH VFSGPSLVHC
     GPVSHVRMVI APDGGISRLR IWGRPVSSHQ MISKL