ID   ALLC_DICDI              Reviewed;         369 AA.
AC   Q54VL5; Q5D6A3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Allantoicase;
DE            EC=3.5.3.4;
DE   AltName: Full=Allantoate amidinohydrolase;
GN   Name=allC; ORFNames=DDB_G0280267;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 61-238.
RA   Hou L.S., Ma N.S.;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 126-136; 235-244; 253-262 AND 305-333, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=AX2;
RA   Bienvenut W.V., Ura S., Insall R.H.;
RL   Submitted (JUL-2009) to UniProtKB.
CC   -!- FUNCTION: Utilization of purines as secondary nitrogen sources, when
CC       primary sources are limiting. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC         Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC       ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX18646.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AAFI02000035; EAL67360.1; -; Genomic_DNA.
DR   EMBL; AY894718; AAX18646.1; ALT_FRAME; mRNA.
DR   RefSeq; XP_641340.1; XM_636248.1.
DR   AlphaFoldDB; Q54VL5; -.
DR   SMR; Q54VL5; -.
DR   STRING; 44689.DDB0231471; -.
DR   PaxDb; Q54VL5; -.
DR   PRIDE; Q54VL5; -.
DR   EnsemblProtists; EAL67360; EAL67360; DDB_G0280267.
DR   GeneID; 8622474; -.
DR   KEGG; ddi:DDB_G0280267; -.
DR   dictyBase; DDB_G0280267; allC.
DR   eggNOG; KOG4145; Eukaryota.
DR   HOGENOM; CLU_038797_1_2_1; -.
DR   InParanoid; Q54VL5; -.
DR   OMA; MDDGWET; -.
DR   PhylomeDB; Q54VL5; -.
DR   BRENDA; 3.5.3.4; 1939.
DR   UniPathway; UPA00395; UER00654.
DR   PRO; PR:Q54VL5; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019954; P:asexual reproduction; IMP:dictyBase.
DR   GO; GO:0010467; P:gene expression; IMP:dictyBase.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00813; Allantoicase; 1.
DR   InterPro; IPR005164; Allantoicase.
DR   InterPro; IPR015908; Allantoicase_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12045; PTHR12045; 1.
DR   Pfam; PF03561; Allantoicase; 2.
DR   PIRSF; PIRSF016516; Allantoicase; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   TIGRFAMs; TIGR02961; allantoicase; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Purine metabolism;
KW   Reference proteome.
FT   CHAIN           1..369
FT                   /note="Allantoicase"
FT                   /id="PRO_0000328153"
FT   REGION          341..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        83
FT                   /note="K -> N (in Ref. 2; AAX18646)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   369 AA;  41778 MW;  CAEB56829C1B44B7 CRC64;
     MVYANNNIDP NAPCYVSECA ELLSDKVGGV VLGCTDQWFA ECVNLIKHSA PVWDAEKYVD
     TGKWMDGWET KRHNPDHDWC IIKLGIPGVI YGFEIDTAYF TGNYPPHASI EALCDDSDPN
     FNTLKESNNW EVILNKSDLG SSCKKYFECK VEKRFTHIKF RIYPDGGVAR LRAYGRVVKD
     WTLVIPGELV DLAAIENGGL VTQVSDHFYG NKNNIIMPGR SVNMGDGWET KRRRGPGNDW
     LTVKLAKEGI VKRIEVDTNW FKGNFPTSCS IDAIHSSSAP DETHLQDYEW TNILPNSPLC
     GHRRHFFQNE LVNNDKPFTH IRLNIFPDGG VSRLRINCSL PDSKNNNNNN NNNNNNNTSN
     SFKTSDRQQ