ALLC_HUMAN
ID ALLC_HUMAN Reviewed; 391 AA.
AC Q8N6M5; B4DY77; Q53T95; Q5RL81; Q96RE6; Q9NZA7;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-APR-2018, sequence version 4.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Probable inactive allantoicase;
DE AltName: Full=Allantoate amidinohydrolase;
GN Name=ALLC {ECO:0000312|HGNC:HGNC:17377};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Fetal spleen;
RX PubMed=11054555; DOI=10.1016/s0378-1119(00)00342-5;
RA Vigetti D., Monetti C., Acquati F., Taramelli R., Bernardini G.;
RT "Human allantoicase gene: cDNA cloning, genomic organization and chromosome
RT localization.";
RL Gene 256:253-260(2000).
RN [2] {ECO:0000312|EMBL:BAG63639.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis {ECO:0000312|EMBL:BAG63639.1};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4] {ECO:0000312|EMBL:EAX01050.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND
RP VARIANT ALA-ASP-ALA-PRO-LYS-GLU-GLY-ARG-LEU-THR-ARG-PHE-LEU-ASP-PHE-THR-
RP GLN-LEU-MET-1 INS.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 16-353 (ISOFORM 1), GENE STRUCTURE, AND
RP FUNCTION.
RX PubMed=12036579; DOI=10.1016/s0378-1119(02)00541-3;
RA Vigetti D., Monetti C., Prati M., Gornati R., Bernardini G.;
RT "Genomic organization and chromosome localization of the murine and human
RT allantoicase gene.";
RL Gene 289:13-17(2002).
CC -!- FUNCTION: The function of this enzyme is unclear as allantoicase
CC activity is not known to exist in mammals.
CC {ECO:0000305|PubMed:12036579}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N6M5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N6M5-2; Sequence=VSP_015618;
CC -!- POLYMORPHISM: Product of a polymorphic gene which also produces a
CC longer 410-residue protein due to a polymorphism which affects Met-1,
CC resulting in a longer protein starting at an upstream Met.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000305}.
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DR EMBL; AF215924; AAF67097.1; -; mRNA.
DR EMBL; AK302299; BAG63639.1; -; mRNA.
DR EMBL; AC010907; AAY24236.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX01050.1; -; Genomic_DNA.
DR EMBL; BC029652; AAH29652.1; -; mRNA.
DR EMBL; BC035356; AAH35356.1; -; mRNA.
DR EMBL; AF395820; AAK72970.1; -; mRNA.
DR CCDS; CCDS46223.1; -. [Q8N6M5-1]
DR RefSeq; NP_060906.3; NM_018436.3. [Q8N6M5-1]
DR AlphaFoldDB; Q8N6M5; -.
DR SMR; Q8N6M5; -.
DR BioGRID; 120929; 2.
DR IntAct; Q8N6M5; 2.
DR MINT; Q8N6M5; -.
DR STRING; 9606.ENSP00000252505; -.
DR iPTMnet; Q8N6M5; -.
DR PhosphoSitePlus; Q8N6M5; -.
DR BioMuta; ALLC; -.
DR DMDM; 327478594; -.
DR MassIVE; Q8N6M5; -.
DR PaxDb; Q8N6M5; -.
DR PeptideAtlas; Q8N6M5; -.
DR PRIDE; Q8N6M5; -.
DR ProteomicsDB; 5505; -.
DR ProteomicsDB; 72193; -. [Q8N6M5-1]
DR Antibodypedia; 26390; 94 antibodies from 21 providers.
DR DNASU; 55821; -.
DR Ensembl; ENST00000252505.4; ENSP00000252505.3; ENSG00000151360.10. [Q8N6M5-1]
DR GeneID; 55821; -.
DR KEGG; hsa:55821; -.
DR MANE-Select; ENST00000252505.4; ENSP00000252505.3; NM_018436.4; NP_060906.3.
DR UCSC; uc010ewt.4; human.
DR CTD; 55821; -.
DR DisGeNET; 55821; -.
DR GeneCards; ALLC; -.
DR HGNC; HGNC:17377; ALLC.
DR HPA; ENSG00000151360; Tissue enriched (testis).
DR MIM; 612396; gene.
DR neXtProt; NX_Q8N6M5; -.
DR OpenTargets; ENSG00000151360; -.
DR PharmGKB; PA24720; -.
DR VEuPathDB; HostDB:ENSG00000151360; -.
DR eggNOG; KOG4145; Eukaryota.
DR GeneTree; ENSGT00390000001793; -.
DR HOGENOM; CLU_038797_1_2_1; -.
DR InParanoid; Q8N6M5; -.
DR OMA; MDDGWET; -.
DR OrthoDB; 563639at2759; -.
DR PhylomeDB; Q8N6M5; -.
DR TreeFam; TF324677; -.
DR PathwayCommons; Q8N6M5; -.
DR SignaLink; Q8N6M5; -.
DR BioGRID-ORCS; 55821; 18 hits in 1074 CRISPR screens.
DR ChiTaRS; ALLC; human.
DR GenomeRNAi; 55821; -.
DR Pharos; Q8N6M5; Tdark.
DR PRO; PR:Q8N6M5; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8N6M5; protein.
DR Bgee; ENSG00000151360; Expressed in sperm and 102 other tissues.
DR GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-EC.
DR GO; GO:0000256; P:allantoin catabolic process; IEA:InterPro.
DR HAMAP; MF_00813; Allantoicase; 1.
DR InterPro; IPR005164; Allantoicase.
DR InterPro; IPR015908; Allantoicase_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12045; PTHR12045; 1.
DR Pfam; PF03561; Allantoicase; 2.
DR PIRSF; PIRSF016516; Allantoicase; 1.
DR SUPFAM; SSF49785; SSF49785; 2.
DR TIGRFAMs; TIGR02961; allantoicase; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..391
FT /note="Probable inactive allantoicase"
FT /id="PRO_0000205905"
FT VAR_SEQ 1..229
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11054555,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_015618"
FT VARIANT 1
FT /note="M -> MADAPKEGRLTRFLDFTQLM"
FT /id="VAR_080299"
FT CONFLICT 110
FT /note="T -> I (in Ref. 5; AAH29652 and 6; AAK72970)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="L -> P (in Ref. 6; AAK72970)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="Missing (in Ref. 1; AAF67097, 5; AAH29652 and 6;
FT AAK72970)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 391 AA; 43559 MW; C8B5FFDD67BE0B9B CRC64;
MDMASESVGG KILFATDDFF APAENLIKSD SPCFKEHEYT EFGKWMDGWE TRRKRIPGHD
WCVLRLGIQG VIRGFDVDVS YFTGDYAPRV SIQAANLEED KLPEIPERGT RTGAAATPEE
FEAIAELKSD DWSYLVPMTE LKPGNPASGH NYFLVNSQQR WTHIRLNIFP DGGIARLRVF
GTGQKDWTAT DPKEPADLVA IAFGGVCVGF SNAKFGHPNN IIGVGGAKSM ADGWETARRL
DRPPILENDE NGILLVPGCE WAVFRLAHPG VITRIEIDTK YFEGNAPDSC KVDGCILTTQ
EEEAVIRQKW ILPAHKWKPL LPVTKLSPNQ SHLFDSLTLE LQDVITHARL TIVPDGGVSR
LRLRGFPSSI CLLRPREKPM LKFSVSFKAN P
