ID   3NX3_SISCA              Reviewed;          89 AA.
AC   A5X2W8; B4Y146;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Three-finger toxin 3 {ECO:0000312|EMBL:ABG27006.1, ECO:0000312|EMBL:ABZ89720.1};
DE   Flags: Precursor;
OS   Sistrurus catenatus edwardsii (Desert massasauga) (Crotalophorus
OS   edwardsii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Sistrurus.
OX   NCBI_TaxID=8762;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kini R.M., Mackessy S.P., Pahari S.;
RT   "cDNA clones from a library of Sistrurus catenatus edwardsii venom gland.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=18606022; DOI=10.1186/1471-2148-8-196;
RA   Doley R., Pahari S., Mackessy S.P., Kini R.M.;
RT   "Accelerated exchange of exon segments in Viperid three-finger toxin genes
RT   (Sistrurus catenatus edwardsii; Desert Massasauga).";
RL   BMC Evol. Biol. 8:196-196(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Ancestral
CC       subfamily. {ECO:0000305}.
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DR   EMBL; DQ464283; ABG27006.1; -; mRNA.
DR   EMBL; EU293793; ABZ89720.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5X2W8; -.
DR   SMR; A5X2W8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   InterPro; IPR035076; Toxin/TOLIP.
DR   Pfam; PF00087; Toxin_TOLIP; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..89
FT                   /note="Three-finger toxin 3"
FT                   /id="PRO_0000316183"
FT   DISULFID        24..47
FT   DISULFID        40..66
FT   DISULFID        70..81
FT   DISULFID        82..87
SQ   SEQUENCE   89 AA;  9999 MW;  3DD98BC933176427 CRC64;
     MKTLLLILGV VAFVYLEPGY TTNCFTCTTW TLSCREFEKC PPDKGTCFKR WNSTGIAIRR
     RYTRGCAAAC PNPVGNEKVF CCVTDNCNK