ALLC_MOUSE
ID ALLC_MOUSE Reviewed; 414 AA.
AC Q9JHX6; E9QL21;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Probable inactive allantoicase;
DE AltName: Full=Allantoate amidinohydrolase;
GN Name=Allc {ECO:0000312|MGI:MGI:2136971};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1;
RX PubMed=11406280; DOI=10.1016/s0167-4781(01)00207-x;
RA Vigetti D., Monetti C., Bernardini G.;
RT "Molecular cloning of mouse allantoicase cDNA.";
RL Biochim. Biophys. Acta 1519:117-121(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP GENE STRUCTURE, AND FUNCTION.
RX PubMed=12036579; DOI=10.1016/s0378-1119(02)00541-3;
RA Vigetti D., Monetti C., Prati M., Gornati R., Bernardini G.;
RT "Genomic organization and chromosome localization of the murine and human
RT allantoicase gene.";
RL Gene 289:13-17(2002).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: The function of this enzyme is unclear as allantoicase
CC activity is not known to exist in mammals.
CC {ECO:0000305|PubMed:12036579}.
CC -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000305}.
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DR EMBL; AF278712; AAF86348.1; -; mRNA.
DR EMBL; AC165283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS25850.1; -.
DR RefSeq; NP_444386.2; NM_053156.2.
DR RefSeq; XP_006515350.1; XM_006515287.1.
DR AlphaFoldDB; Q9JHX6; -.
DR SMR; Q9JHX6; -.
DR STRING; 10090.ENSMUSP00000020965; -.
DR PhosphoSitePlus; Q9JHX6; -.
DR REPRODUCTION-2DPAGE; Q9JHX6; -.
DR PaxDb; Q9JHX6; -.
DR PRIDE; Q9JHX6; -.
DR ProteomicsDB; 296173; -.
DR Antibodypedia; 26390; 94 antibodies from 21 providers.
DR DNASU; 94041; -.
DR Ensembl; ENSMUST00000020965; ENSMUSP00000020965; ENSMUSG00000020636.
DR Ensembl; ENSMUST00000110917; ENSMUSP00000106542; ENSMUSG00000020636.
DR GeneID; 94041; -.
DR KEGG; mmu:94041; -.
DR UCSC; uc007nfp.3; mouse.
DR CTD; 55821; -.
DR MGI; MGI:2136971; Allc.
DR VEuPathDB; HostDB:ENSMUSG00000020636; -.
DR eggNOG; KOG4145; Eukaryota.
DR GeneTree; ENSGT00390000001793; -.
DR HOGENOM; CLU_038797_1_2_1; -.
DR InParanoid; Q9JHX6; -.
DR OMA; MDDGWET; -.
DR OrthoDB; 563639at2759; -.
DR PhylomeDB; Q9JHX6; -.
DR TreeFam; TF324677; -.
DR BRENDA; 3.5.3.4; 3474.
DR BioGRID-ORCS; 94041; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q9JHX6; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9JHX6; protein.
DR Bgee; ENSMUSG00000020636; Expressed in spermatid and 30 other tissues.
DR Genevisible; Q9JHX6; MM.
DR GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-EC.
DR GO; GO:0000256; P:allantoin catabolic process; IEA:InterPro.
DR HAMAP; MF_00813; Allantoicase; 1.
DR InterPro; IPR005164; Allantoicase.
DR InterPro; IPR015908; Allantoicase_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12045; PTHR12045; 1.
DR Pfam; PF03561; Allantoicase; 2.
DR PIRSF; PIRSF016516; Allantoicase; 1.
DR SUPFAM; SSF49785; SSF49785; 2.
DR TIGRFAMs; TIGR02961; allantoicase; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..414
FT /note="Probable inactive allantoicase"
FT /id="PRO_0000205907"
FT CONFLICT 2
FT /note="T -> A (in Ref. 1; AAF86348)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="D -> G (in Ref. 1; AAF86348)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 414 AA; 46294 MW; A7BD1FDB443AE177 CRC64;
MTDTPKEGKL TRFLDFTQLI DLASECVGGK VLFATDDFFG PAENLIKSDS PTFKEHEYTE
FGKWVDGWET RRKRIPGHDW CVIQLGIQGI IRGIDVDISY FSGNHAPRMS IQAANLSEED
TMSNIPPRGV RMGTAATPEE FEAVTELKSH SWDYLVPMSE LKLGDPDSSH NYYFVNSQQR
WTHIRLNIFP DGGVARLRVY GTGQRDWAAL DSTEPVDLVA IAFGGVCVGF SNAHFGHPNN
MIGVGEPKSI ADGWETARRL DRPPVLEASE NGLLLVPGCE WAVFRLAHPG VITQIEIDTK
YFKGNCPNSC KVDGCILTTL EEEDMIRHNW NLPAHKWKSL LPVTKLIPNQ NHLLDSLTLE
LQDVITHAMI TIAPDGGVSR LRLKGFPSSI CLLRPLREKP LLRFSLKTGF RANL