ALLC_NEUCR
ID ALLC_NEUCR Reviewed; 354 AA.
AC P18407; Q7RXF0;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 09-MAY-2003, sequence version 2.
DT 25-MAY-2022, entry version 135.
DE RecName: Full=Allantoicase;
DE EC=3.5.3.4;
GN Name=alc-1; Synonyms=alc; ORFNames=B8B8.070, NCU01816;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=2148685; DOI=10.1021/bi00489a039;
RA Lee H., Fu Y.H., Marzluf G.A.;
RT "Nucleotide sequence and DNA recognition elements of alc, the structural
RT gene which encodes allantoicase, a purine catabolic enzyme of Neurospora
RT crassa.";
RL Biochemistry 29:8779-8787(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Utilization of purines as secondary nitrogen sources, when
CC primary sources are limiting.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC -!- INDUCTION: Induced by uric acid. Repressed by nitrogen.
CC -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000305}.
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DR EMBL; J02927; AAA33556.1; -; Genomic_DNA.
DR EMBL; BX284761; CAD70499.1; -; Genomic_DNA.
DR EMBL; CM002237; EAA27258.1; -; Genomic_DNA.
DR PIR; A35829; A35829.
DR RefSeq; XP_956494.1; XM_951401.2.
DR AlphaFoldDB; P18407; -.
DR SMR; P18407; -.
DR STRING; 5141.EFNCRP00000001652; -.
DR EnsemblFungi; EAA27258; EAA27258; NCU01816.
DR GeneID; 3872616; -.
DR KEGG; ncr:NCU01816; -.
DR VEuPathDB; FungiDB:NCU01816; -.
DR HOGENOM; CLU_038797_0_0_1; -.
DR InParanoid; P18407; -.
DR UniPathway; UPA00395; UER00654.
DR Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR GO; GO:0004037; F:allantoicase activity; IBA:GO_Central.
DR GO; GO:0000256; P:allantoin catabolic process; IBA:GO_Central.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR HAMAP; MF_00813; Allantoicase; 1.
DR InterPro; IPR005164; Allantoicase.
DR InterPro; IPR015908; Allantoicase_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12045; PTHR12045; 1.
DR Pfam; PF03561; Allantoicase; 2.
DR PIRSF; PIRSF016516; Allantoicase; 1.
DR SUPFAM; SSF49785; SSF49785; 2.
DR TIGRFAMs; TIGR02961; allantoicase; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Purine metabolism; Reference proteome.
FT CHAIN 1..354
FT /note="Allantoicase"
FT /id="PRO_0000205912"
FT CONFLICT 42
FT /note="L -> S (in Ref. 1; AAA33556)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="R -> L (in Ref. 1; AAA33556)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="G -> C (in Ref. 1; AAA33556)"
FT /evidence="ECO:0000305"
FT CONFLICT 288
FT /note="A -> R (in Ref. 1; AAA33556)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="E -> R (in Ref. 1; AAA33556)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 354 AA; 39073 MW; 302761471D1A253F CRC64;
MTDIDYKLEA VPATRIAADD IDKTFRSSTI DLISGALGGK VLGFSDEWFA EAANLLTPTA
PIRQPGKMVY TGAWYDGWET RRHNPAEFDW VVIRLGVASG TVEGVEIDTA FFNGNHAPAI
SVEGCFSQND DEVLSWKGER GGWETILGVQ ECGPSQRFGW KLENPTKKQY THVRLNMYPD
GGIARFRLFG HAVPVFPDNT DAIFDLAAAQ NGGVAISCSD QHFGTKDNLI LPGRGKDMGD
GWETARSRTK GHVDWTIIRL GAPGYIQNFM VDTAHFRGNY PQQVKLQAIE WKSEGEPGAD
SEGWTEVVEP IKCGPDQEHP VESLVKDKPF THVKLIIVPD GGVKRLRVFA KRAV
