ID   ALLC_STRCO              Reviewed;         376 AA.
AC   Q9RKU4;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Probable allantoicase {ECO:0000255|HAMAP-Rule:MF_00813};
DE            EC=3.5.3.4 {ECO:0000255|HAMAP-Rule:MF_00813};
DE   AltName: Full=Allantoate amidinohydrolase {ECO:0000255|HAMAP-Rule:MF_00813};
GN   Name=alc {ECO:0000255|HAMAP-Rule:MF_00813}; OrderedLocusNames=SCO6248;
GN   ORFNames=SCAH10.13, STAH10.13;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC         Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00813};
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC       ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00813}.
CC   -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000255|HAMAP-
CC       Rule:MF_00813}.
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DR   EMBL; AL939126; CAB60167.1; -; Genomic_DNA.
DR   RefSeq; NP_630348.1; NC_003888.3.
DR   RefSeq; WP_011030765.1; NZ_VNID01000009.1.
DR   AlphaFoldDB; Q9RKU4; -.
DR   SMR; Q9RKU4; -.
DR   STRING; 100226.SCO6248; -.
DR   GeneID; 1101689; -.
DR   KEGG; sco:SCO6248; -.
DR   PATRIC; fig|100226.15.peg.6362; -.
DR   eggNOG; COG4266; Bacteria.
DR   HOGENOM; CLU_038797_1_0_11; -.
DR   InParanoid; Q9RKU4; -.
DR   OMA; MDDGWET; -.
DR   PhylomeDB; Q9RKU4; -.
DR   UniPathway; UPA00395; UER00654.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00813; Allantoicase; 1.
DR   InterPro; IPR005164; Allantoicase.
DR   InterPro; IPR015908; Allantoicase_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12045; PTHR12045; 1.
DR   Pfam; PF03561; Allantoicase; 2.
DR   PIRSF; PIRSF016516; Allantoicase; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   TIGRFAMs; TIGR02961; allantoicase; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Purine metabolism; Reference proteome.
FT   CHAIN           1..376
FT                   /note="Probable allantoicase"
FT                   /id="PRO_0000205929"
SQ   SEQUENCE   376 AA;  41208 MW;  2247C0B2300C4A29 CRC64;
     MTAQQNTSLA SFTGDAQPYG GGDPYADYRT ADLPFTQYAN LADRQLGAGV VAANDEFFAQ
     RENLLVPEPA EFDPEHFGHK GKVMDGWETR RRRGVSAEQP WPTEEDHDWA LIRLGAPGVI
     RGIVVDTAHF RGNYPQAVSV EGASVAGSPS PEELLADDVK WTTLVPRTPV GGHAANGFAV
     SAEQRFTHLR LKQHPDGGIA RLRVYGEVVA DPAWLAALGT FDVVALENGG QVEDASNLFY
     SPATNTIQPG RSRKMDDGWE TRRRRDKGND WIQYRLVDRS QIRAIEIDTA YLKGNSAGWA
     SVSVKDGEAG EWREVLPRTR MQPDTNHRFV LPEAAVGTHA RVDIFPDGGI SRLRLFGSLT
     EDGAARLAAR HQELGG