ALLC_XENLA
ID ALLC_XENLA Reviewed; 389 AA.
AC Q9W6S5; Q6PA96;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Allantoicase;
DE EC=3.5.3.4;
DE AltName: Full=Allantoate amidinohydrolase;
GN Name=allc;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Brain, Kidney, and Liver;
RX PubMed=10864446; DOI=10.1006/abbi.2000.1863;
RA Vigetti D., Monetti C., Pollegioni L., Taramelli R., Bernardini G.;
RT "Xenopus allantoicase: molecular cloning, enzymatic activity and
RT developmental expression.";
RL Arch. Biochem. Biophys. 379:90-96(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Utilization of purines as secondary nitrogen sources, when
CC primary sources are limiting. {ECO:0000269|PubMed:10864446}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC -!- TISSUE SPECIFICITY: Abundantly expressed in kidney and liver, but at
CC much lower level is also present in brain, testis, intestine and lung.
CC {ECO:0000269|PubMed:10864446}.
CC -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000305}.
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DR EMBL; AF153230; AAD34169.1; -; mRNA.
DR EMBL; BC060404; AAH60404.1; -; mRNA.
DR RefSeq; NP_001083467.1; NM_001089998.1.
DR AlphaFoldDB; Q9W6S5; -.
DR SMR; Q9W6S5; -.
DR DNASU; 398942; -.
DR GeneID; 398942; -.
DR KEGG; xla:398942; -.
DR CTD; 398942; -.
DR Xenbase; XB-GENE-1002648; allc.L.
DR OrthoDB; 563639at2759; -.
DR BRENDA; 3.5.3.4; 6725.
DR SABIO-RK; Q9W6S5; -.
DR UniPathway; UPA00395; UER00654.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 398942; Expressed in kidney and 5 other tissues.
DR GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-EC.
DR GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR HAMAP; MF_00813; Allantoicase; 1.
DR InterPro; IPR005164; Allantoicase.
DR InterPro; IPR015908; Allantoicase_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12045; PTHR12045; 1.
DR Pfam; PF03561; Allantoicase; 2.
DR PIRSF; PIRSF016516; Allantoicase; 1.
DR SUPFAM; SSF49785; SSF49785; 2.
DR TIGRFAMs; TIGR02961; allantoicase; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Purine metabolism; Reference proteome.
FT CHAIN 1..389
FT /note="Allantoicase"
FT /id="PRO_0000205910"
FT CONFLICT 111
FT /note="I -> V (in Ref. 2; AAH60404)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 389 AA; 43764 MW; C62EBC2AD3A2875F CRC64;
MFAHPKENIA LPVPEFLQMN NLACESVGGK VLFATDDWFA PAEHLLKKTE PEFKVGLFTE
FGKWMDGWET RRKRIPGHDW CIIQLGVPGI IHGFEADTRF FTGNYAPRIS IQAACLKPEE
ITLQPREDKI GTAASDEEFK AADKLKSEKW SHLLKMTELK PGYAESSHSY FQVNSKERWT
HLRLNIYPDG GIARFKVYGI GQRDWTSCGP NDFEDLLSMV NGGVCLGFSD AHYGHPRNLI
GNGRACDMGD GWETARRLDR PPILKADSKG ILQVPGFEWA VLKLGHPGLV THIEIDTNHF
KGNSPNSCKI DACALKPTEQ EEVKGHGNFE QGYNWKPLLP VTQIHPHKRH FMESTSLALH
QVISHVKITI APDGGVSRIR LWGFPRPLP