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ALLC_XENLA
ID   ALLC_XENLA              Reviewed;         389 AA.
AC   Q9W6S5; Q6PA96;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Allantoicase;
DE            EC=3.5.3.4;
DE   AltName: Full=Allantoate amidinohydrolase;
GN   Name=allc;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Brain, Kidney, and Liver;
RX   PubMed=10864446; DOI=10.1006/abbi.2000.1863;
RA   Vigetti D., Monetti C., Pollegioni L., Taramelli R., Bernardini G.;
RT   "Xenopus allantoicase: molecular cloning, enzymatic activity and
RT   developmental expression.";
RL   Arch. Biochem. Biophys. 379:90-96(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Utilization of purines as secondary nitrogen sources, when
CC       primary sources are limiting. {ECO:0000269|PubMed:10864446}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC         Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC       ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC   -!- TISSUE SPECIFICITY: Abundantly expressed in kidney and liver, but at
CC       much lower level is also present in brain, testis, intestine and lung.
CC       {ECO:0000269|PubMed:10864446}.
CC   -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000305}.
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DR   EMBL; AF153230; AAD34169.1; -; mRNA.
DR   EMBL; BC060404; AAH60404.1; -; mRNA.
DR   RefSeq; NP_001083467.1; NM_001089998.1.
DR   AlphaFoldDB; Q9W6S5; -.
DR   SMR; Q9W6S5; -.
DR   DNASU; 398942; -.
DR   GeneID; 398942; -.
DR   KEGG; xla:398942; -.
DR   CTD; 398942; -.
DR   Xenbase; XB-GENE-1002648; allc.L.
DR   OrthoDB; 563639at2759; -.
DR   BRENDA; 3.5.3.4; 6725.
DR   SABIO-RK; Q9W6S5; -.
DR   UniPathway; UPA00395; UER00654.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 398942; Expressed in kidney and 5 other tissues.
DR   GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00813; Allantoicase; 1.
DR   InterPro; IPR005164; Allantoicase.
DR   InterPro; IPR015908; Allantoicase_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12045; PTHR12045; 1.
DR   Pfam; PF03561; Allantoicase; 2.
DR   PIRSF; PIRSF016516; Allantoicase; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   TIGRFAMs; TIGR02961; allantoicase; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Purine metabolism; Reference proteome.
FT   CHAIN           1..389
FT                   /note="Allantoicase"
FT                   /id="PRO_0000205910"
FT   CONFLICT        111
FT                   /note="I -> V (in Ref. 2; AAH60404)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   389 AA;  43764 MW;  C62EBC2AD3A2875F CRC64;
     MFAHPKENIA LPVPEFLQMN NLACESVGGK VLFATDDWFA PAEHLLKKTE PEFKVGLFTE
     FGKWMDGWET RRKRIPGHDW CIIQLGVPGI IHGFEADTRF FTGNYAPRIS IQAACLKPEE
     ITLQPREDKI GTAASDEEFK AADKLKSEKW SHLLKMTELK PGYAESSHSY FQVNSKERWT
     HLRLNIYPDG GIARFKVYGI GQRDWTSCGP NDFEDLLSMV NGGVCLGFSD AHYGHPRNLI
     GNGRACDMGD GWETARRLDR PPILKADSKG ILQVPGFEWA VLKLGHPGLV THIEIDTNHF
     KGNSPNSCKI DACALKPTEQ EEVKGHGNFE QGYNWKPLLP VTQIHPHKRH FMESTSLALH
     QVISHVKITI APDGGVSRIR LWGFPRPLP
 
 
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