ID   ALLC_XENTR              Reviewed;         389 AA.
AC   Q640T1; Q8JHV2;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Allantoicase;
DE            EC=3.5.3.4;
DE   AltName: Full=Allantoate amidinohydrolase;
GN   Name=allc;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 66-258.
RX   PubMed=14745534; DOI=10.1007/s00239-003-2515-5;
RA   Vigetti D., Binelli G., Monetti C., Prati M., Bernardini G., Gornati R.;
RT   "Selective pressure on the allantoicase gene during vertebrate evolution.";
RL   J. Mol. Evol. 57:650-658(2003).
CC   -!- FUNCTION: Utilization of purines as secondary nitrogen sources, when
CC       primary sources are limiting. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC         Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC       ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the allantoicase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC082508; AAH82508.1; -; mRNA.
DR   EMBL; AF480058; AAM74031.1; -; mRNA.
DR   RefSeq; NP_001162026.1; NM_001168554.1.
DR   AlphaFoldDB; Q640T1; -.
DR   SMR; Q640T1; -.
DR   PaxDb; Q640T1; -.
DR   GeneID; 394447; -.
DR   KEGG; xtr:394447; -.
DR   CTD; 55821; -.
DR   Xenbase; XB-GENE-1002643; allc.
DR   eggNOG; KOG4145; Eukaryota.
DR   InParanoid; Q640T1; -.
DR   OrthoDB; 563639at2759; -.
DR   UniPathway; UPA00395; UER00654.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00813; Allantoicase; 1.
DR   InterPro; IPR005164; Allantoicase.
DR   InterPro; IPR015908; Allantoicase_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12045; PTHR12045; 1.
DR   Pfam; PF03561; Allantoicase; 2.
DR   PIRSF; PIRSF016516; Allantoicase; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   TIGRFAMs; TIGR02961; allantoicase; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Purine metabolism; Reference proteome.
FT   CHAIN           1..389
FT                   /note="Allantoicase"
FT                   /id="PRO_0000205911"
FT   CONFLICT        257
FT                   /note="R -> S (in Ref. 2; AAM74031)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   389 AA;  43618 MW;  EBFF4D5AC4DE6741 CRC64;
     MSAPPKENIG LPVSEFVQMN NLACESVGGK VLFATDDCFA PAENLLKKKD PEFKPGLFTE
     FGKWMDGWET RRKRIPGHDW CIIELGVPGI IHGFEADTRF FTGNYAPRIS VQAACLKPEE
     ITFQPRKDKI GTAASIEEYK SADKLKSEKW SHLLQMTELT PGYAESSHSY FNVNSKQRWT
     HLRLNIYPDG GIARFKVYGI GQRDWSSCKP NDLEDLLSMV NGGVCLGFSD AHYGHPRNLI
     GIGRACDMGD GWETARRLDR PPVLKADSKG ILQVPGFEWA VLKLGHPGLV THIEIDTNHF
     KGNSPNSCKI DACALTPTEE EGVKRDERFE IGYNWKPLLS VTQIHPHKRR YVESTSLALH
     QVISHVKITI APDGGVSRIR LWGFPRPLP