ID   ALLH_AGRFC              Reviewed;         162 AA.
AC   Q8UFI8;
DT   12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Putative ureidoglycolate lyase;
DE            EC=4.3.2.3;
GN   OrderedLocusNames=Atu1409; ORFNames=AGR_C_2603;
OS   Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS   (strain C58)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA   Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA   Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA   Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA   Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA   Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA   Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA   Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA   Gordon M.P., Olson M.V., Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA   Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA   Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA   Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA   Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
CC   -!- FUNCTION: Catalyzes the catabolism of the allantoin degradation
CC       intermediate (S)-ureidoglycolate, generating urea and glyoxylate.
CC       Involved in the utilization of allantoin as nitrogen source (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-ureidoglycolate = glyoxylate + urea; Xref=Rhea:RHEA:11304,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:36655, ChEBI:CHEBI:57296; EC=4.3.2.3;
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence={ECO:0000250};
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ureidoglycolate lyase family. {ECO:0000305}.
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DR   EMBL; AE007869; AAK87201.1; -; Genomic_DNA.
DR   PIR; AI2749; AI2749.
DR   PIR; H97530; H97530.
DR   RefSeq; NP_354416.1; NC_003062.2.
DR   RefSeq; WP_010971600.1; NC_003062.2.
DR   AlphaFoldDB; Q8UFI8; -.
DR   SMR; Q8UFI8; -.
DR   STRING; 176299.Atu1409; -.
DR   EnsemblBacteria; AAK87201; AAK87201; Atu1409.
DR   KEGG; atu:Atu1409; -.
DR   PATRIC; fig|176299.10.peg.1432; -.
DR   eggNOG; COG3194; Bacteria.
DR   HOGENOM; CLU_070848_1_0_5; -.
DR   OMA; PLNDKPY; -.
DR   PhylomeDB; Q8UFI8; -.
DR   BioCyc; AGRO:ATU1409-MON; -.
DR   UniPathway; UPA00395; -.
DR   Proteomes; UP000000813; Chromosome circular.
DR   GO; GO:0004848; F:ureidoglycolate hydrolase activity; IEA:InterPro.
DR   GO; GO:0050385; F:ureidoglycolate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.480; -; 1.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   InterPro; IPR007247; Ureidogly_lyase.
DR   InterPro; IPR024060; Ureidoglycolate_lyase_dom_sf.
DR   PANTHER; PTHR21221; PTHR21221; 1.
DR   Pfam; PF04115; Ureidogly_lyase; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   3: Inferred from homology;
KW   Lyase; Purine metabolism; Reference proteome.
FT   CHAIN           1..162
FT                   /note="Putative ureidoglycolate lyase"
FT                   /id="PRO_0000120560"
SQ   SEQUENCE   162 AA;  17318 MW;  9FEA308131284E0F CRC64;
     MKTVTARPLT AEAFAPYGSV ADISELENLV SLADAYEGTG EAKTPVLQLV QAKAMSGSPV
     ISQMEIHPFS SQTFLPLDQS SSLIVVCEAG EDGMPDESTI KAFLASPSQI VTYRHGVMHH
     RLTPLAPSGR FAMTMWQTGR GGDTVLYPLH TPVSVDISDI TP