ID   ALLIU_ALLSA             Reviewed;          10 AA.
AC   P84796;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Alliumin;
DE   Flags: Fragment;
OS   Allium sativum (Garlic).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Amaryllidaceae;
OC   Allioideae; Allieae; Allium.
OX   NCBI_TaxID=4682;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Bulb {ECO:0000269|PubMed:15629528};
RX   PubMed=15629528; DOI=10.1016/j.peptides.2004.09.019;
RA   Xia L., Ng T.B.;
RT   "Isolation of alliumin, a novel protein with antimicrobial and
RT   antiproliferative activities from multiple-cloved garlic bulbs.";
RL   Peptides 26:177-183(2005).
CC   -!- FUNCTION: Has antifungal activity against M.arachidicola with an IC(50)
CC       of 1.3 uM, but not against F.oxysporum. Has antibacterial activity
CC       against the Gram-negative bacterium P.fluorescens. No antibacterial
CC       activity against the Gram-positive bacteria B.subtilis, B.cereus and
CC       B.megaterium, or against the Gram-negative bacterium E.coli. Has
CC       antiproliferative activity towards L1210 leukemia cells with an IC(50)
CC       of 8.33 uM, but lacks antiproliferative activity towards HepG2 hepatoma
CC       cells. Lacks mitogenic towards murine splenocytes. Lacks ribonuclease
CC       activity towards yeast tRNA and protease activity towards casein.
CC       {ECO:0000269|PubMed:15629528}.
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DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide.
FT   CHAIN           1..>10
FT                   /note="Alliumin"
FT                   /evidence="ECO:0000269|PubMed:15629528"
FT                   /id="PRO_0000229757"
FT   NON_TER         10
FT                   /evidence="ECO:0000303|PubMed:15629528"
SQ   SEQUENCE   10 AA;  1013 MW;  DD2EEC787DDEB729 CRC64;
     DDFLCAGGCL