ALLP_HELAM
ID ALLP_HELAM Reviewed; 225 AA.
AC O44314;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Helicostatins;
DE Contains:
DE RecName: Full=Helicostatin-1;
DE AltName: Full=Helicostatin I;
DE Contains:
DE RecName: Full=Helicostatin-2a;
DE AltName: Full=Helicostatin IIa;
DE Contains:
DE RecName: Full=Helicostatin-2b;
DE AltName: Full=Helicostatin IIb;
DE Contains:
DE RecName: Full=Helicostatin-3;
DE AltName: Full=Helicostatin III;
DE Contains:
DE RecName: Full=Helicostatin-4;
DE AltName: Full=Helicostatin IV;
DE Contains:
DE RecName: Full=Helicostatin-5;
DE AltName: Full=Helicostatin V;
DE Contains:
DE RecName: Full=Helicostatin-6;
DE AltName: Full=Helicostatin VI;
DE Contains:
DE RecName: Full=Helicostatin-7;
DE AltName: Full=Helicostatin VII;
DE Contains:
DE RecName: Full=Helicostatin-8;
DE AltName: Full=Helicostatin VIII;
DE Contains:
DE RecName: Full=Helicostatin-9;
DE AltName: Full=Helicostatin IX;
DE Flags: Precursor;
OS Helicoverpa armigera (Cotton bollworm) (Heliothis armigera).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Helicoverpa.
OX NCBI_TaxID=29058;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC TISSUE=CNS, and Gut;
RX PubMed=10612045; DOI=10.1016/s0965-1748(99)00092-2;
RA Davey M., Duve H., Thorpe A., East P.;
RT "Characterisation of the helicostatin peptide precursor gene from
RT Helicoverpa armigera (Lepidoptera: Noctuidae).";
RL Insect Biochem. Mol. Biol. 29:1119-1127(1999).
RN [2]
RP PROTEIN SEQUENCE OF 51-58; 62-79; 83-90; 130-137; 152-159; 163-170;
RP 174-181; 185-192 AND 196-206, AND AMIDATION AT LEU-58; LEU-79; LEU-90;
RP LEU-137; LEU-159; LEU-170; LEU-181; LEU-192 AND LEU-206.
RC TISSUE=Larva;
RX PubMed=9392829; DOI=10.1016/s0196-9781(97)00188-5;
RA Duve H., Johnsen A.H., Maestro J.-L., Scott A.G., Winstanley D., Davey M.,
RA East P.D., Thorpe A.;
RT "Lepidopteran peptides of the allatostatin superfamily.";
RL Peptides 18:1301-1309(1997).
CC -!- FUNCTION: May act as a neurotransmitter or neuromodulator.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Highly expressed in the CNS and gut of larvae. Also
CC expressed in the cells of the larval brain and ventral nerve cord and
CC in endocrine cells of the midgut. {ECO:0000269|PubMed:10612045}.
CC -!- SIMILARITY: Belongs to the allatostatin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF015296; AAB94674.1; -; Genomic_DNA.
DR AlphaFoldDB; O44314; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR010276; Allatostatin.
DR Pfam; PF05953; Allatostatin; 9.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..48
FT /id="PRO_0000001164"
FT PEPTIDE 51..58
FT /note="Helicostatin-1"
FT /id="PRO_0000001165"
FT PEPTIDE 62..79
FT /note="Helicostatin-2a"
FT /id="PRO_0000001166"
FT PEPTIDE 72..79
FT /note="Helicostatin-2b"
FT /id="PRO_0000001167"
FT PEPTIDE 83..90
FT /note="Helicostatin-3"
FT /id="PRO_0000001168"
FT PROPEP 94..127
FT /id="PRO_0000001169"
FT PEPTIDE 130..137
FT /note="Helicostatin-4"
FT /id="PRO_0000001170"
FT PROPEP 141..149
FT /id="PRO_0000001171"
FT PEPTIDE 152..159
FT /note="Helicostatin-5"
FT /id="PRO_0000001172"
FT PEPTIDE 163..170
FT /note="Helicostatin-6"
FT /id="PRO_0000001173"
FT PEPTIDE 174..181
FT /note="Helicostatin-7"
FT /id="PRO_0000001174"
FT PEPTIDE 185..192
FT /note="Helicostatin-8"
FT /id="PRO_0000001175"
FT PEPTIDE 196..206
FT /note="Helicostatin-9"
FT /id="PRO_0000001176"
FT PROPEP 210..225
FT /id="PRO_0000001177"
FT REGION 205..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 58
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:9392829"
FT MOD_RES 79
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:9392829"
FT MOD_RES 90
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:9392829"
FT MOD_RES 137
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:9392829"
FT MOD_RES 159
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:9392829"
FT MOD_RES 170
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:9392829"
FT MOD_RES 181
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:9392829"
FT MOD_RES 192
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:9392829"
FT MOD_RES 206
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:9392829"
SQ SEQUENCE 225 AA; 25631 MW; A7A2C3B3047EF4F4 CRC64;
MLYSSLPVCF LVLGAALCAP ERMQNEAEPH DLQPHEAEPH SDHVAPLAKR SPHYDFGLGK
RAYSYVSEYK RLPVYNFGLG KRSRPYSFGL GKRSVDEDQS NDEQQLTTSD LDQAALAELF
DQYDDAEKRA RPYSFGLGKR FADDETSEEK RARAYDFGLG KRLPMYNFGL GKRARSYNFG
LGKRYSKFNF GLGKRERDMH RFSFGLGKRS GDDVSADDSD NYFDV
