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ALLR_KLEPN
ID   ALLR_KLEPN              Reviewed;         272 AA.
AC   Q765S0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=HTH-type transcriptional repressor AllR;
DE   AltName: Full=Negative regulator of allantoin and glyoxylate utilization operons;
GN   Name=allR;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15213119; DOI=10.1128/iai.72.7.3783-3792.2004;
RA   Chou H.-C., Lee C.-Z., Ma L.-C., Fang C.-T., Chang S.-C., Wang J.-T.;
RT   "Isolation of a chromosomal region of Klebsiella pneumoniae associated with
RT   allantoin metabolism and liver infection.";
RL   Infect. Immun. 72:3783-3792(2004).
CC   -!- FUNCTION: Negative regulator of allantoin and glyoxylate utilization
CC       operons. Binds to the gcl promoter and to the allS-allA intergenic
CC       region (By similarity). {ECO:0000250}.
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DR   EMBL; AB115590; BAD14990.1; -; Genomic_DNA.
DR   RefSeq; WP_012737529.1; NZ_WYAM01000013.1.
DR   AlphaFoldDB; Q765S0; -.
DR   SMR; Q765S0; -.
DR   GeneID; 61331630; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..272
FT                   /note="HTH-type transcriptional repressor AllR"
FT                   /id="PRO_0000313701"
FT   DOMAIN          21..83
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DOMAIN          98..267
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT   DNA_BIND        43..62
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         154..156
FT                   /ligand="glyoxylate"
FT                   /ligand_id="ChEBI:CHEBI:36655"
FT                   /evidence="ECO:0000250"
FT   BINDING         207
FT                   /ligand="glyoxylate"
FT                   /ligand_id="ChEBI:CHEBI:36655"
FT                   /evidence="ECO:0000250"
FT   BINDING         217
FT                   /ligand="glyoxylate"
FT                   /ligand_id="ChEBI:CHEBI:36655"
FT                   /evidence="ECO:0000250"
FT   BINDING         234..236
FT                   /ligand="glyoxylate"
FT                   /ligand_id="ChEBI:CHEBI:36655"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   272 AA;  29286 MW;  29E733EDA217332A CRC64;
     MTEVRRRGRP GQQEPSAQKG AQALERGIAI LQYLEKSGGS SSVSDISLNL DLPLSTTFRL
     LKVLEGADFV YQDSQLGWWH IGLGAFNIGS AYIHNRDVLS VGGPFMRRLM LMSGETVNVA
     IRNGNEAVLI GQQECKSMVR MCAPLGSRLP LHASGAGKAL LYPLPAEELV DVIVKTGLQR
     FTPTTIVDLP VLQRNLDEAR ACGYSIDQEE HVTGLNCIAS AVYDDVGSVV AAISISGPAS
     RLTPDRFVSQ GELVRETARN ISTALGLKPQ AD
 
 
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