ALLR_KLEPN
ID ALLR_KLEPN Reviewed; 272 AA.
AC Q765S0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=HTH-type transcriptional repressor AllR;
DE AltName: Full=Negative regulator of allantoin and glyoxylate utilization operons;
GN Name=allR;
OS Klebsiella pneumoniae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15213119; DOI=10.1128/iai.72.7.3783-3792.2004;
RA Chou H.-C., Lee C.-Z., Ma L.-C., Fang C.-T., Chang S.-C., Wang J.-T.;
RT "Isolation of a chromosomal region of Klebsiella pneumoniae associated with
RT allantoin metabolism and liver infection.";
RL Infect. Immun. 72:3783-3792(2004).
CC -!- FUNCTION: Negative regulator of allantoin and glyoxylate utilization
CC operons. Binds to the gcl promoter and to the allS-allA intergenic
CC region (By similarity). {ECO:0000250}.
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DR EMBL; AB115590; BAD14990.1; -; Genomic_DNA.
DR RefSeq; WP_012737529.1; NZ_WYAM01000013.1.
DR AlphaFoldDB; Q765S0; -.
DR SMR; Q765S0; -.
DR GeneID; 61331630; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..272
FT /note="HTH-type transcriptional repressor AllR"
FT /id="PRO_0000313701"
FT DOMAIN 21..83
FT /note="HTH iclR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT DOMAIN 98..267
FT /note="IclR-ED"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT DNA_BIND 43..62
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 154..156
FT /ligand="glyoxylate"
FT /ligand_id="ChEBI:CHEBI:36655"
FT /evidence="ECO:0000250"
FT BINDING 207
FT /ligand="glyoxylate"
FT /ligand_id="ChEBI:CHEBI:36655"
FT /evidence="ECO:0000250"
FT BINDING 217
FT /ligand="glyoxylate"
FT /ligand_id="ChEBI:CHEBI:36655"
FT /evidence="ECO:0000250"
FT BINDING 234..236
FT /ligand="glyoxylate"
FT /ligand_id="ChEBI:CHEBI:36655"
FT /evidence="ECO:0000250"
SQ SEQUENCE 272 AA; 29286 MW; 29E733EDA217332A CRC64;
MTEVRRRGRP GQQEPSAQKG AQALERGIAI LQYLEKSGGS SSVSDISLNL DLPLSTTFRL
LKVLEGADFV YQDSQLGWWH IGLGAFNIGS AYIHNRDVLS VGGPFMRRLM LMSGETVNVA
IRNGNEAVLI GQQECKSMVR MCAPLGSRLP LHASGAGKAL LYPLPAEELV DVIVKTGLQR
FTPTTIVDLP VLQRNLDEAR ACGYSIDQEE HVTGLNCIAS AVYDDVGSVV AAISISGPAS
RLTPDRFVSQ GELVRETARN ISTALGLKPQ AD