ALLS_APIME
ID ALLS_APIME Reviewed; 197 AA.
AC P85797; D5L5R2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 25-MAY-2022, entry version 51.
DE RecName: Full=Allatostatins;
DE Contains:
DE RecName: Full=Allatostatin-1;
DE Short=AST1;
DE Contains:
DE RecName: Full=Allatostatin-2a;
DE Short=AST2a;
DE Contains:
DE RecName: Full=Allatostatin-2b;
DE Short=AST2b;
DE Contains:
DE RecName: Full=Allatostatin-3;
DE Short=AST3;
DE Contains:
DE RecName: Full=Allatostatin-4;
DE Short=AST4;
DE Contains:
DE RecName: Full=Allatostatin-5;
DE Short=AST5;
DE Contains:
DE RecName: Full=Allatostatin-6;
DE Short=AST6;
DE Contains:
DE RecName: Full=Allatostatin-7a;
DE Short=AST7a;
DE Contains:
DE RecName: Full=Allatostatin-7b;
DE Short=AST7b;
DE Contains:
DE RecName: Full=Allatostatin-7c;
DE Short=AST7c;
DE Flags: Precursor;
OS Apis mellifera (Honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC Apis.
OX NCBI_TaxID=7460;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Silva-Torres F.A., Nunes F.M.F., Simoes Z.L.P.;
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH4;
RG Honey bee genome project;
RA Zhang L., Deng J., Wu Y.-Q., Kovar C., Aqrawi P., Bandaranaike D.,
RA Blankenburg K., Chen D., Denson S., Dinh H., Firestine M., Gross S.,
RA Han Y., Hernandez B., Holder M., Jackson L., Javaid M., Jing C., Jones J.,
RA Joshi V., Kamau G., Korchina V., Lee S., Lorensuhewa L., Mata R.,
RA Mathew T., Mims S., Ngo R., Nguyen L., Okwuonu G., Ongeri F., Osuji N.,
RA Pham C., Puazo M., Qu C., Quiroz J., Raj R., Rio Deiros D., Santibanez J.,
RA Scheel M., Scherer S., Vee V., Wang M., Xin Y., Richards S., Reid J.G.,
RA Newsham I., Worley K.C., Muzny D.M., Gibbs R.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP PROTEIN SEQUENCE OF 59-66; 69-76; 89-96; 100-106; 110-143; 146-154 AND
RP 158-184, MASS SPECTROMETRY, AND AMIDATION AT ILE-76; LEU-96; LEU-106;
RP LEU-154 AND LEU-184.
RC TISSUE=Brain {ECO:0000269|PubMed:17068263};
RX PubMed=17068263; DOI=10.1126/science.1124128;
RA Hummon A.B., Richmond T.A., Verleyen P., Baggerman G., Huybrechts J.,
RA Ewing M.A., Vierstraete E., Rodriguez-Zas S.L., Schoofs L., Robinson G.E.,
RA Sweedler J.V.;
RT "From the genome to the proteome: uncovering peptides in the Apis brain.";
RL Science 314:647-649(2006).
CC -!- FUNCTION: Neuropeptides. {ECO:0000250|UniProtKB:P12764}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P12764}.
CC -!- MASS SPECTROMETRY: [Allatostatin-1]: Mass=994.43; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Allatostatin-2a]: Mass=920.51; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Allatostatin-2b]: Mass=751.39; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Allatostatin-3]: Mass=912.45; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Allatostatin-4]: Mass=868.46; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Allatostatin-5]: Mass=3992.8; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Allatostatin-6]: Mass=1022.53; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Allatostatin-7a]: Mass=3013.51;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Allatostatin-7b]: Mass=1171.56;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Allatostatin-7c]: Mass=1575.76;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC -!- SIMILARITY: Belongs to the allatostatin family. {ECO:0000255}.
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DR EMBL; GU785070; ADE45320.1; -; mRNA.
DR EMBL; AADG06003262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001161181.1; NM_001167709.1.
DR AlphaFoldDB; P85797; -.
DR STRING; 7460.GB47928-PA; -.
DR PaxDb; P85797; -.
DR EnsemblMetazoa; NM_001167709; NP_001161181; GeneID_724880.
DR GeneID; 724880; -.
DR KEGG; ame:724880; -.
DR CTD; 724880; -.
DR eggNOG; ENOG502S9TT; Eukaryota.
DR HOGENOM; CLU_111722_0_0_1; -.
DR InParanoid; P85797; -.
DR OMA; EKRAYAY; -.
DR OrthoDB; 1309198at2759; -.
DR PhylomeDB; P85797; -.
DR Proteomes; UP000005203; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT PROPEP 28..56
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341452"
FT PEPTIDE 59..66
FT /note="Allatostatin-1"
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341453"
FT PEPTIDE 69..76
FT /note="Allatostatin-2a"
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341454"
FT PEPTIDE 69..74
FT /note="Allatostatin-2b"
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341455"
FT PROPEP 80..86
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341456"
FT PEPTIDE 89..96
FT /note="Allatostatin-3"
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341457"
FT PEPTIDE 100..106
FT /note="Allatostatin-4"
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341458"
FT PEPTIDE 110..143
FT /note="Allatostatin-5"
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341459"
FT PEPTIDE 146..154
FT /note="Allatostatin-6"
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341460"
FT PEPTIDE 158..184
FT /note="Allatostatin-7a"
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341461"
FT PEPTIDE 158..169
FT /note="Allatostatin-7b"
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341462"
FT PEPTIDE 172..184
FT /note="Allatostatin-7c"
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341463"
FT PROPEP 188..197
FT /evidence="ECO:0000269|PubMed:17068263"
FT /id="PRO_0000341464"
FT REGION 161..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 76
FT /note="Isoleucine amide"
FT /evidence="ECO:0000269|PubMed:17068263"
FT MOD_RES 96
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:17068263"
FT MOD_RES 106
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:17068263"
FT MOD_RES 154
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:17068263"
FT MOD_RES 184
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:17068263"
SQ SEQUENCE 197 AA; 22787 MW; E03D35FF352252E4 CRC64;
MRSRTSVLTS SLAFLYFFGI VGRSALAMEE TPASSMNLQH YNNMLNPMVF DDTMPEKRAY
TYVSEYKRLP VYNFGIGKRW IDTNDNKRGR DYSFGLGKRR QYSFGLGKRN DNADYPLRLN
LDYLPVDNPA FHSQENTDDF LEEKRGRQPY SFGLGKRAVH YSGGQPLGSK RPNDMLSQRY
HFGLGKRMSE DEEESSQ
