ID   ALLS_MANSE              Reviewed;          15 AA.
AC   P42559;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   02-JUN-2021, entry version 53.
DE   RecName: Full=Allatostatin;
DE            Short=Mas-AS;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND FUNCTION.
RC   TISSUE=Head {ECO:0000303|PubMed:1946359};
RX   PubMed=1946359; DOI=10.1073/pnas.88.21.9458;
RA   Kramer S.J., Toschi A., Miller C.A., Kataoka H., Quistad G.B., Li J.P.,
RA   Carney R.L., Schooley D.A.;
RT   "Identification of an allatostatin from the tobacco hornworm Manduca
RT   sexta.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:9458-9462(1991).
CC   -!- FUNCTION: Strongly inhibits juvenile hormone biosynthesis in vitro by
CC       the corpora allata from fifth-stadium larvae and adult females.
CC       {ECO:0000269|PubMed:1946359}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the allatostatin family. {ECO:0000305}.
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DR   PIR; A61612; A61612.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IDA:UniProtKB.
DR   GO; GO:0045968; P:negative regulation of juvenile hormone biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; TAS:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Neuropeptide; Pyrrolidone carboxylic acid;
KW   Secreted.
FT   PEPTIDE         1..15
FT                   /note="Allatostatin"
FT                   /id="PRO_0000043456"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:1946359"
SQ   SEQUENCE   15 AA;  1908 MW;  1605B77CDEBC838E CRC64;
     QVRFRQCYFN PISCF