ID   ALLS_SPOFR              Reviewed;         125 AA.
AC   Q868F8;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Allatostatin;
DE            Short=AS;
DE            Short=Spofr-AS;
DE   Flags: Precursor;
GN   Name=ast {ECO:0000312|EMBL:CAD32496.1};
OS   Spodoptera frugiperda (Fall armyworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Amphipyrinae; Spodoptera.
OX   NCBI_TaxID=7108;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAD32496.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Brain {ECO:0000269|PubMed:12706626};
RX   PubMed=12706626; DOI=10.1016/s0965-1748(03)00005-5;
RA   Abdel-latief M., Meyering-Vos M., Hoffmann K.H.;
RT   "Molecular characterisation of cDNAs from the fall armyworm Spodoptera
RT   frugiperda encoding Manduca sexta allatotropin and allatostatin
RT   preprohormone peptides.";
RL   Insect Biochem. Mol. Biol. 33:467-476(2003).
CC   -!- FUNCTION: Strongly inhibits juvenile hormone biosynthesis in vitro by
CC       the corpora allata from fifth-stadium larvae and adult females.
CC       {ECO:0000250|UniProtKB:P42559}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Highest level in adult female brain, lower levels
CC       in adult male brain. Expressed in the brain of sixth larval stage with
CC       decreasing levels in prepupae, young pupae and 10 day old pupae.
CC       {ECO:0000269|PubMed:12706626}.
CC   -!- SIMILARITY: Belongs to the allatostatin family. {ECO:0000255}.
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DR   EMBL; AJ488181; CAD32496.1; -; mRNA.
DR   AlphaFoldDB; Q868F8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0045968; P:negative regulation of juvenile hormone biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..106
FT                   /evidence="ECO:0000250|UniProtKB:P42559, ECO:0000255"
FT                   /id="PRO_0000001154"
FT   PEPTIDE         109..123
FT                   /note="Allatostatin"
FT                   /evidence="ECO:0000250|UniProtKB:P42559"
FT                   /id="PRO_0000001155"
FT   MOD_RES         109
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P42559"
SQ   SEQUENCE   125 AA;  14099 MW;  3C53117896BC6B23 CRC64;
     MKTSAYNVYL GVVAAMLALL FVTINAAPME ADDETAENTL VAHPDGDMEL SGPWDAINTA
     ALRKLLLQLD AEDRMGGVTR SWPQAEPRGW GLRALDSRLA RQWRADKRQV RFRQCYFNPI
     SCFRK