ID   ALMA1_DURXX             Reviewed;         301 AA.
AC   P0DN22;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Dimethylsulfonioproprionate lyase {ECO:0000305};
DE            Short=DMSP lyase {ECO:0000305};
DE            EC=4.4.1.3 {ECO:0000269|PubMed:26113722};
DE   AltName: Full=Symbiodinium-A1 {ECO:0000303|PubMed:26113722};
GN   Name=ALMA1 {ECO:0000303|PubMed:26113722};
OS   Durusdinium sp. clade D (Symbiodinium sp. clade D).
OC   Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC   Symbiodinium.
OX   NCBI_TaxID=298137;
RN   [1]
RP   IDENTIFICATION, FUNCTION, CATALYTIC ACTIVITY, AND INDUCTION.
RX   PubMed=26113722; DOI=10.1126/science.aab1586;
RA   Alcolombri U., Ben-Dor S., Feldmesser E., Levin Y., Tawfik D.S., Vardi A.;
RT   "Identification of the algal dimethyl sulfide-releasing enzyme: A missing
RT   link in the marine sulfur cycle.";
RL   Science 348:1466-1469(2015).
CC   -!- FUNCTION: Mediates cleavage of dimethylsulfonioproprionate (DMSP) into
CC       dimethyl sulfide (DMS) and acrylate. DMS is the principal form by which
CC       sulfur is transported from oceans to the atmosphere and is a key
CC       component of the ocean sulfur cycle. {ECO:0000269|PubMed:26113722}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide +
CC         H(+); Xref=Rhea:RHEA:19965, ChEBI:CHEBI:15378, ChEBI:CHEBI:16457,
CC         ChEBI:CHEBI:17437, ChEBI:CHEBI:37080; EC=4.4.1.3;
CC         Evidence={ECO:0000250|UniProtKB:P0DN21};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:P0DN21}.
CC   -!- INDUCTION: Expressed at low level. {ECO:0000269|PubMed:26113722}.
CC   -!- MISCELLANEOUS: At least 10 million metric tons of volatile dimethyl
CC       sulfide (DMS) are released into the atmosphere annually by the
CC       dimethylsulfonioproprionate lyase in oceans. It is a component of the
CC       tangy aroma of the seaside and functions as a chemical attractant that
CC       guides various marine animals, such as sea birds, invertebrates, and
CC       some mammals, toward potential food supplies. DMS oxidation products
CC       act as condensation nuclei, causing water molecules to coalesce, with
CC       possible effects on local climate through enhanced cloud formation.
CC       {ECO:0000305|PubMed:26113722}.
CC   -!- SIMILARITY: Belongs to the aspartate/glutamate racemases family. ALMA1
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0DN22; -.
DR   SMR; P0DN22; -.
DR   GO; GO:0047869; F:dimethylpropiothetin dethiomethylase activity; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Lyase.
FT   CHAIN           1..301
FT                   /note="Dimethylsulfonioproprionate lyase"
FT                   /id="PRO_0000433887"
FT   ACT_SITE        111
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P0DN21"
FT   ACT_SITE        230
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P0DN21"
SQ   SEQUENCE   301 AA;  33143 MW;  7A2B7F2EBC99F368 CRC64;
     MPLILGGLAG AAAGYGAAAW LERRKPPPGK DPNIKHASLG VVRLDWHYHP LPGDVGSPDS
     FEYPVYYRAV PGLTFEICQS GKMSPEIQQN FKDAIEFLDK ERGVSVITSD CGFFMWFQKE
     ARLYTSKPVV MSSLALLPSL HAAIGTDGKI AIFSANSTSL GPMHDTVAKE CGVDWDEACY
     VLVGCQDVEG FEAVASGEPL DLEKVTPGIV RKAKQVIAEH PDIHAILMEC TQLPPFSDDV
     RAATGLPVYD AIVSADFFIR GFVDNPRFGL NDWHRPWDGH QEKYKLGDNV QDKEKLLHYK
     P