ID   ALMA5_EMIHU             Reviewed;         504 AA.
AC   R1ENF4;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2013, sequence version 1.
DT   03-AUG-2022, entry version 27.
DE   RecName: Full=Dimethylsulfonioproprionate lyase 5 {ECO:0000305};
DE            Short=DMSP lyase 5 {ECO:0000305};
DE            EC=4.4.1.3 {ECO:0000250|UniProtKB:P0DN21};
DE   AltName: Full=Dimethylpropiothetin dethiomethylase 5 {ECO:0000305};
GN   Name=ALMA5 {ECO:0000303|PubMed:26113722};
GN   ORFNames=EMIHUDRAFT_115912 {ECO:0000312|EMBL:EOD24466.1};
OS   Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC   Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC   Noelaerhabdaceae; Emiliania.
OX   NCBI_TaxID=2903;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1516;
RX   PubMed=23760476; DOI=10.1038/nature12221;
RA   Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA   Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA   Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA   Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA   Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA   Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA   Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA   Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA   Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA   Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA   Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA   Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA   Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA   van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA   Wurch L.L.;
RT   "Pan genome of the phytoplankton Emiliania underpins its global
RT   distribution.";
RL   Nature 499:209-213(2013).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=26113722; DOI=10.1126/science.aab1586;
RA   Alcolombri U., Ben-Dor S., Feldmesser E., Levin Y., Tawfik D.S., Vardi A.;
RT   "Identification of the algal dimethyl sulfide-releasing enzyme: A missing
RT   link in the marine sulfur cycle.";
RL   Science 348:1466-1469(2015).
CC   -!- FUNCTION: Mediates cleavage of dimethylsulfonioproprionate (DMSP) into
CC       dimethyl sulfide (DMS) and acrylate. DMS is the principal form by which
CC       sulfur is transported from oceans to the atmosphere and is a key
CC       component of the ocean sulfur cycle. {ECO:0000250|UniProtKB:P0DN21}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide +
CC         H(+); Xref=Rhea:RHEA:19965, ChEBI:CHEBI:15378, ChEBI:CHEBI:16457,
CC         ChEBI:CHEBI:17437, ChEBI:CHEBI:37080; EC=4.4.1.3;
CC         Evidence={ECO:0000250|UniProtKB:P0DN21};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:P0DN21}.
CC   -!- SIMILARITY: Belongs to the aspartate/glutamate racemases family. ALMA1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; KB865438; EOD24466.1; -; Genomic_DNA.
DR   RefSeq; XP_005776895.1; XM_005776838.1.
DR   AlphaFoldDB; R1ENF4; -.
DR   SMR; R1ENF4; -.
DR   GeneID; 17270012; -.
DR   KEGG; ehx:EMIHUDRAFT_115912; -.
DR   eggNOG; ENOG502RZWQ; Eukaryota.
DR   HOGENOM; CLU_567962_0_0_1; -.
DR   Proteomes; UP000013827; Unassembled WGS sequence.
DR   GO; GO:0047869; F:dimethylpropiothetin dethiomethylase activity; IEA:UniProtKB-EC.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..504
FT                   /note="Dimethylsulfonioproprionate lyase 5"
FT                   /id="PRO_0000433892"
SQ   SEQUENCE   504 AA;  54753 MW;  057BB71C5C8B3486 CRC64;
     MPAQAVVGTN SYLFRTVHAE VKGLRYLDVR AGKELSVSQK KALKEAVKEL DAEGVVAITG
     DCGSFVHYQT AVRRMTKTPA VLSPLLQAPL LATMYMKEET ILVLTNDSSD YDQAALESNL
     VEIGLSQEDA ARFVIQGLQH IEGFSTSEVA DMSDERTWAM VDTSERLRLE IMSTIEAAKK
     ANPSLRAILL ESTLLPSFSD SMRQTRGVPV FDAITLADYL AAASTDNPRF GSNIDASVWS
     SAMERANVMD ELSQRATPAI GILRIDYSYP PAPGDVDYPG SYYYRTVQEV AAGLTFEAAQ
     EGRPLTAQQR EAMEGAIRRL EAAKGVVGIT GDCGFLMNYQ VDARRMSHLP CFISAMMQCH
     MLAASFAADE EFLVLTANGK SLAPKFGEML SLAHVTRPED QARFHILGCE DVDGFDAVAK
     GEAVDVARVT PGIVALAKAA AARRPKVRAV LLECTELPPY ADALRHALRI PVLDAITLVD
     FVHSASTDNP AFGVDFQKSS KVFV