ID   ALMA6_EMIHU             Reviewed;         383 AA.
AC   R1F493;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2013, sequence version 1.
DT   03-AUG-2022, entry version 20.
DE   RecName: Full=Dimethylsulfonioproprionate lyase 6 {ECO:0000305};
DE            Short=DMSP lyase 6 {ECO:0000305};
DE            EC=4.4.1.3 {ECO:0000250|UniProtKB:P0DN21};
DE   AltName: Full=Dimethylpropiothetin dethiomethylase 6 {ECO:0000305};
GN   Name=ALMA6 {ECO:0000303|PubMed:26113722};
GN   ORFNames=EMIHUDRAFT_111561 {ECO:0000312|EMBL:EOD33735.1};
OS   Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC   Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC   Noelaerhabdaceae; Emiliania.
OX   NCBI_TaxID=2903;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1516;
RX   PubMed=23760476; DOI=10.1038/nature12221;
RA   Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA   Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA   Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA   Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA   Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA   Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA   Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA   Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA   Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA   Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA   Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA   Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA   Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA   van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA   Wurch L.L.;
RT   "Pan genome of the phytoplankton Emiliania underpins its global
RT   distribution.";
RL   Nature 499:209-213(2013).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=26113722; DOI=10.1126/science.aab1586;
RA   Alcolombri U., Ben-Dor S., Feldmesser E., Levin Y., Tawfik D.S., Vardi A.;
RT   "Identification of the algal dimethyl sulfide-releasing enzyme: A missing
RT   link in the marine sulfur cycle.";
RL   Science 348:1466-1469(2015).
CC   -!- FUNCTION: Mediates cleavage of dimethylsulfonioproprionate (DMSP) into
CC       dimethyl sulfide (DMS) and acrylate. DMS is the principal form by which
CC       sulfur is transported from oceans to the atmosphere and is a key
CC       component of the ocean sulfur cycle. {ECO:0000250|UniProtKB:P0DN21}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide +
CC         H(+); Xref=Rhea:RHEA:19965, ChEBI:CHEBI:15378, ChEBI:CHEBI:16457,
CC         ChEBI:CHEBI:17437, ChEBI:CHEBI:37080; EC=4.4.1.3;
CC         Evidence={ECO:0000250|UniProtKB:P0DN21};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:P0DN21}.
CC   -!- SIMILARITY: Belongs to the aspartate/glutamate racemases family. ALMA1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; KB864391; EOD33735.1; -; Genomic_DNA.
DR   RefSeq; XP_005786164.1; XM_005786107.1.
DR   AlphaFoldDB; R1F493; -.
DR   SMR; R1F493; -.
DR   GeneID; 17279005; -.
DR   KEGG; ehx:EMIHUDRAFT_111561; -.
DR   eggNOG; ENOG502RZWQ; Eukaryota.
DR   HOGENOM; CLU_722474_0_0_1; -.
DR   Proteomes; UP000013827; Unassembled WGS sequence.
DR   GO; GO:0047869; F:dimethylpropiothetin dethiomethylase activity; IEA:UniProtKB-EC.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..383
FT                   /note="Dimethylsulfonioproprionate lyase 6"
FT                   /id="PRO_0000433893"
SQ   SEQUENCE   383 AA;  42120 MW;  B28F36FC3A014149 CRC64;
     MGCAGSTLRS GASFEDSRLA AIEDSRFHEV GHHAQFEDSR LAAIEDSRFH EVGHHAQFDE
     GGRFKQLPPA NDDAKLLVAD HPSLGVIRLD YDYPPALGDV DHPGSFYYDV FYRVVPGLTF
     ELCQSGELPD DVKQRFIDAI TWLDEQGVAG ITGDCGFFMY FQALARSVTS KPVFMSSLCQ
     LPAVVCAYAA DEHIALFTAN GESLKPMREL IKKECGVDPD DTRFVIVGCE DVPGFEAVAN
     GDRVDVDSVL PHLVRLAEDT VAKHAGTAKP IRAILFECTE LPPYSDAVRA ATRLPVFDSI
     TCCNSMLASL MDNPRFGVNN WHLSWDGAHT AHRFGDNVPP HLKGKLVNRE HPENVARWNA
     SLAERSSFSS AQQESIGRGS REL