ID   GCST_HALSA              Reviewed;         363 AA.
AC   Q9HPJ7;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2003, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Probable aminomethyltransferase {ECO:0000255|HAMAP-Rule:MF_00259};
DE            EC=2.1.2.10 {ECO:0000255|HAMAP-Rule:MF_00259};
DE   AltName: Full=Glycine cleavage system T protein {ECO:0000255|HAMAP-Rule:MF_00259};
GN   Name=gcvT {ECO:0000255|HAMAP-Rule:MF_00259}; Synonyms=gcvT1;
GN   OrderedLocusNames=VNG_1606G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. {ECO:0000255|HAMAP-Rule:MF_00259}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-
CC         aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-
CC         5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] +
CC         NH4(+); Xref=Rhea:RHEA:16945, Rhea:RHEA-COMP:10475, Rhea:RHEA-
CC         COMP:10492, ChEBI:CHEBI:15636, ChEBI:CHEBI:28938, ChEBI:CHEBI:57453,
CC         ChEBI:CHEBI:83100, ChEBI:CHEBI:83143; EC=2.1.2.10;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00259};
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins: P,
CC       T, L and H. {ECO:0000255|HAMAP-Rule:MF_00259}.
CC   -!- SIMILARITY: Belongs to the GcvT family. {ECO:0000255|HAMAP-
CC       Rule:MF_00259}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG19870.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE004437; AAG19870.1; ALT_INIT; Genomic_DNA.
DR   PIR; B84313; B84313.
DR   RefSeq; WP_010903168.1; NC_002607.1.
DR   AlphaFoldDB; Q9HPJ7; -.
DR   SMR; Q9HPJ7; -.
DR   STRING; 64091.VNG_1606G; -.
DR   PaxDb; Q9HPJ7; -.
DR   EnsemblBacteria; AAG19870; AAG19870; VNG_1606G.
DR   GeneID; 5953781; -.
DR   KEGG; hal:VNG_1606G; -.
DR   PATRIC; fig|64091.14.peg.1223; -.
DR   HOGENOM; CLU_007884_10_2_2; -.
DR   InParanoid; Q9HPJ7; -.
DR   OrthoDB; 25548at2157; -.
DR   PhylomeDB; Q9HPJ7; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0004047; F:aminomethyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1360.120; -; 1.
DR   HAMAP; MF_00259; GcvT; 1.
DR   InterPro; IPR006223; GCS_T.
DR   InterPro; IPR022903; GCS_T_bac.
DR   InterPro; IPR028896; GCST/YgfZ/DmdA.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR43757; PTHR43757; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; SSF101790; 1.
DR   TIGRFAMs; TIGR00528; gcvT; 1.
PE   3: Inferred from homology;
KW   Aminotransferase; Reference proteome; Transferase.
FT   CHAIN           1..363
FT                   /note="Probable aminomethyltransferase"
FT                   /id="PRO_0000122622"
SQ   SEQUENCE   363 AA;  38199 MW;  FD25399E1A94FE70 CRC64;
     MGLRTSPLHG RHEDRGASFT EFGGWNMPVD FDGIQAEHAA VREAAGIFDV SHMGEIEVSG
     PDAERLMQRL TTNDVSRLDP GDAQYAAITD DDGIMIDDTV VYRTPADWPG AFLFVPNAGH
     DAAAFDRWTD HRDAHDLDAS VDNVTTDYGM VAVQGPDAPD LVAARAGDGV HDLGRFEAAT
     VGVAGVECLV ANTGYTGEAG VEIVFPADGA GAVWDAIAND CQPCGLGARD TLRMEHGFLL
     SGQDFDPEEN PRTPFEAGIG FAVAPESGFV GRDALADTDS PEQQFVGLTL DERGVPRHGY
     AVTTPAGDEI GTVTSGTMSP TLGEPIGLGY VDSAHAADGT TVAVRIRGTD KQATITTPPF
     LDQ