ID   GCST_MYCA1              Reviewed;         367 AA.
AC   A0QEZ6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Aminomethyltransferase {ECO:0000255|HAMAP-Rule:MF_00259};
DE            EC=2.1.2.10 {ECO:0000255|HAMAP-Rule:MF_00259};
DE   AltName: Full=Glycine cleavage system T protein {ECO:0000255|HAMAP-Rule:MF_00259};
GN   Name=gcvT {ECO:0000255|HAMAP-Rule:MF_00259}; OrderedLocusNames=MAV_2280;
OS   Mycobacterium avium (strain 104).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=243243;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=104;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. {ECO:0000255|HAMAP-Rule:MF_00259}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-
CC         aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-
CC         5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] +
CC         NH4(+); Xref=Rhea:RHEA:16945, Rhea:RHEA-COMP:10475, Rhea:RHEA-
CC         COMP:10492, ChEBI:CHEBI:15636, ChEBI:CHEBI:28938, ChEBI:CHEBI:57453,
CC         ChEBI:CHEBI:83100, ChEBI:CHEBI:83143; EC=2.1.2.10;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00259};
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins: P,
CC       T, L and H. {ECO:0000255|HAMAP-Rule:MF_00259}.
CC   -!- SIMILARITY: Belongs to the GcvT family. {ECO:0000255|HAMAP-
CC       Rule:MF_00259}.
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DR   EMBL; CP000479; ABK64607.1; -; Genomic_DNA.
DR   RefSeq; WP_011724703.1; NC_008595.1.
DR   AlphaFoldDB; A0QEZ6; -.
DR   SMR; A0QEZ6; -.
DR   EnsemblBacteria; ABK64607; ABK64607; MAV_2280.
DR   KEGG; mav:MAV_2280; -.
DR   HOGENOM; CLU_007884_10_2_11; -.
DR   OMA; YPLHGQD; -.
DR   OrthoDB; 282830at2; -.
DR   Proteomes; UP000001574; Chromosome.
DR   GO; GO:0004047; F:aminomethyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1360.120; -; 1.
DR   HAMAP; MF_00259; GcvT; 1.
DR   InterPro; IPR006223; GCS_T.
DR   InterPro; IPR022903; GCS_T_bac.
DR   InterPro; IPR028896; GCST/YgfZ/DmdA.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR43757; PTHR43757; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; SSF101790; 1.
DR   TIGRFAMs; TIGR00528; gcvT; 1.
PE   3: Inferred from homology;
KW   Aminotransferase; Transferase.
FT   CHAIN           1..367
FT                   /note="Aminomethyltransferase"
FT                   /id="PRO_1000047679"
SQ   SEQUENCE   367 AA;  38785 MW;  C517058909EA83F4 CRC64;
     MSNEADLLHG PLEDRHRDLG ASFAEFGGWL MPVSYAGTVS EHNATRNAVG LFDVSHLGKA
     LVRGTGAARF VNSALTNDLN RIGPGKAQYT LCCNESGGVI DDLIAYYVDD DEIFLVPNAA
     NTAAVVEALQ GAAPAGVTVS NLHRSYAVLA VQGPRSADVL AELGLPSDMD YMAYADTSFR
     QVPVRVCRTG YTGEHGYELL PPWESAGVVF DALAAAVSQA GGQPAGLGAR DTLRTEMGYP
     LHGHELSPDI SPLQARCGWA IGWKKEAFFG RDALLAEKEA GPRRLLRGLR MVGRGVLRAG
     LTVLVGDTPV GVTTSGTFSP TLQAGIALAL IDTDADVRDG QKVTVDVRGR AATCEVVRPP
     FVAVKTR