ID   GCST_NEIMA              Reviewed;         366 AA.
AC   Q9JVP2; A1IQH7;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Aminomethyltransferase {ECO:0000255|HAMAP-Rule:MF_00259};
DE            EC=2.1.2.10 {ECO:0000255|HAMAP-Rule:MF_00259};
DE   AltName: Full=Glycine cleavage system T protein {ECO:0000255|HAMAP-Rule:MF_00259};
GN   Name=gcvT {ECO:0000255|HAMAP-Rule:MF_00259}; OrderedLocusNames=NMA0758;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. {ECO:0000255|HAMAP-Rule:MF_00259}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-
CC         aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-
CC         5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] +
CC         NH4(+); Xref=Rhea:RHEA:16945, Rhea:RHEA-COMP:10475, Rhea:RHEA-
CC         COMP:10492, ChEBI:CHEBI:15636, ChEBI:CHEBI:28938, ChEBI:CHEBI:57453,
CC         ChEBI:CHEBI:83100, ChEBI:CHEBI:83143; EC=2.1.2.10;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00259};
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins: P,
CC       T, L and H. {ECO:0000255|HAMAP-Rule:MF_00259}.
CC   -!- SIMILARITY: Belongs to the GcvT family. {ECO:0000255|HAMAP-
CC       Rule:MF_00259}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAM08008.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL157959; CAM08008.1; ALT_INIT; Genomic_DNA.
DR   PIR; G81919; G81919.
DR   RefSeq; WP_002233621.1; NC_003116.1.
DR   AlphaFoldDB; Q9JVP2; -.
DR   SMR; Q9JVP2; -.
DR   EnsemblBacteria; CAM08008; CAM08008; NMA0758.
DR   KEGG; nma:NMA0758; -.
DR   HOGENOM; CLU_007884_10_2_4; -.
DR   BioCyc; NMEN122587:NMA_RS03835-MON; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0004047; F:aminomethyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1360.120; -; 1.
DR   HAMAP; MF_00259; GcvT; 1.
DR   InterPro; IPR006223; GCS_T.
DR   InterPro; IPR022903; GCS_T_bac.
DR   InterPro; IPR028896; GCST/YgfZ/DmdA.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR43757; PTHR43757; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; SSF101790; 1.
DR   TIGRFAMs; TIGR00528; gcvT; 1.
PE   3: Inferred from homology;
KW   Aminotransferase; Transferase.
FT   CHAIN           1..366
FT                   /note="Aminomethyltransferase"
FT                   /id="PRO_0000122575"
SQ   SEQUENCE   366 AA;  39623 MW;  D71A1B66EEAD4BE1 CRC64;
     MITLKTTPFH QAHQDAGAKL VDFAGWELPI HYGSQIAEHE AVRTDAGMFD VSHMLVTDVA
     GANAKAFFRK LIANDVAKLA FVGKALYSAL LNDNGGVIDD LIVYRTNEAE TQYRIVSNGA
     TREKDTAQFH KVGQEFGVSF NPRYDLGMLA VQGPKAIEKL LTVKPEWADV VHNLKPFQGA
     DLGNDWFVAR TGYTGEDGVE VILPGTEAVA FFKALQAAGV QPCGLGARDT LRMEAGMNLY
     GNDMDDDTSP LEAGMGWTVD LKDESRDFVG KAALLALKEK GVAVKQVGLL LGKGGILRAH
     MEVLTDKGKG ETTSGVFSPS LKQSIAIARV PKDFDGDTAK VLIRGKEADV RVLKLPFVRN
     GQKQFD