ALMT5_ARATH
ID ALMT5_ARATH Reviewed; 537 AA.
AC Q93Z29; Q9SX23;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Aluminum-activated malate transporter 5;
DE Short=AtALMT5;
GN Name=ALMT5; OrderedLocusNames=At1g68600; ORFNames=F24J5.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16740662; DOI=10.1073/pnas.0602868103;
RA Hoekenga O.A., Maron L.G., Pineros M.A., Cancado G.M., Shaff J.,
RA Kobayashi Y., Ryan P.R., Dong B., Delhaize E., Sasaki T., Matsumoto H.,
RA Yamamoto Y., Koyama H., Kochian L.V.;
RT "AtALMT1, which encodes a malate transporter, is identified as one of
RT several genes critical for aluminum tolerance in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:9738-9743(2006).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=18005230; DOI=10.1111/j.1365-313x.2007.03367.x;
RA Kovermann P., Meyer S., Hoertensteiner S., Picco C., Scholz-Starke J.,
RA Ravera S., Lee Y., Martinoia E.;
RT "The Arabidopsis vacuolar malate channel is a member of the ALMT family.";
RL Plant J. 52:1169-1180(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- FUNCTION: Malate transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the aromatic acid exporter (TC 2.A.85) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD49983.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC008075; AAD49983.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE34818.1; -; Genomic_DNA.
DR EMBL; AY058190; AAL25603.1; -; mRNA.
DR EMBL; AY142004; AAM98268.1; -; mRNA.
DR PIR; D96710; D96710.
DR RefSeq; NP_564935.1; NM_105532.5.
DR AlphaFoldDB; Q93Z29; -.
DR SMR; Q93Z29; -.
DR STRING; 3702.AT1G68600.1; -.
DR TCDB; 2.A.85.2.2; the aromatic acid exporter (arae) family.
DR iPTMnet; Q93Z29; -.
DR PaxDb; Q93Z29; -.
DR PRIDE; Q93Z29; -.
DR ProteomicsDB; 244940; -.
DR EnsemblPlants; AT1G68600.1; AT1G68600.1; AT1G68600.
DR GeneID; 843190; -.
DR Gramene; AT1G68600.1; AT1G68600.1; AT1G68600.
DR KEGG; ath:AT1G68600; -.
DR Araport; AT1G68600; -.
DR TAIR; locus:2026935; AT1G68600.
DR eggNOG; KOG4711; Eukaryota.
DR HOGENOM; CLU_020841_1_2_1; -.
DR InParanoid; Q93Z29; -.
DR OMA; VVLIFEY; -.
DR OrthoDB; 680186at2759; -.
DR PhylomeDB; Q93Z29; -.
DR PRO; PR:Q93Z29; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q93Z29; baseline and differential.
DR Genevisible; Q93Z29; AT.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009705; C:plant-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IEA:UniProt.
DR GO; GO:0015743; P:malate transport; IEA:InterPro.
DR InterPro; IPR020966; ALMT.
DR Pfam; PF11744; ALMT; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Endoplasmic reticulum; Ion channel; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..537
FT /note="Aluminum-activated malate transporter 5"
FT /id="PRO_0000401464"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 373..435
FT /evidence="ECO:0000255"
SQ SEQUENCE 537 AA; 60222 MW; 6259068EF2F1ADA2 CRC64;
MGGKMGSVPE QNTEKLLWQS SDVADSRDSK FRCCSWRALY EAPAKLYALG HSDRRKLYFS
IKMGIALALC SFVIFLKEPL QDASKFAVWA ILTVVLIFEY YVGATLVKGF NRALGTMLAG
GLALGVAQLS VLAGEFEEVI IVICIFLAGF GASYLKLYAS MKPYEYAFRV FKLTYCIVLV
SGNNSRDFLS TAYYRILLIG LGATICLLVN VFLFPIWAGE DLHKLVAKNF KNVANSLEGC
VNGYLQCVEY ERIPSKILTY QASDDPLYSG YRSAVQSTSQ EDSLLDFAIW EPPHGPYKTF
NHPWKNYVKL SGAVRHCAFT VMAMHGCILS EIQASPEKRH VFSNELRRVG NEGAKVLRLF
GEKVEKMEKL SLSLGEILKD VQRAAEALQM KIDSKSYLLV NSESWAAIKE QAEAEEAREN
DQEAKDDETK VIKSLSQIWD TNNNNNHQSN DQSQHWMSTE SMMLKNREMW PSMSFIDGTV
VNEIECKVYE SASSLSLATF ASLLIEFVAR LQNIVNAFEE LSTKAGFKDA VDQIPKV
