ID   GCVA_HAEIN              Reviewed;         301 AA.
AC   P45099;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Glycine cleavage system transcriptional activator homolog;
GN   Name=gcvA; OrderedLocusNames=HI_1194;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Not known, the gcv operon regulated by the E.coli homolog
CC       does not exist in H.influenzae, so it probably acts as a
CC       transcriptional regulator on some other operon.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22848.1; -; Genomic_DNA.
DR   PIR; B64189; B64189.
DR   RefSeq; NP_439350.1; NC_000907.1.
DR   STRING; 71421.HI_1194; -.
DR   EnsemblBacteria; AAC22848; AAC22848; HI_1194.
DR   KEGG; hin:HI_1194; -.
DR   PATRIC; fig|71421.8.peg.1246; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_37_0_6; -.
DR   OMA; IAIYYGK; -.
DR   PhylomeDB; P45099; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..301
FT                   /note="Glycine cleavage system transcriptional activator
FT                   homolog"
FT                   /id="PRO_0000105628"
FT   DOMAIN          10..67
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        27..46
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   301 AA;  34528 MW;  9FA449EA8DB396C8 CRC64;
     MEILMYKRLP PLNSLKSFES AARYLSFTKA ADELCVTQAA VSHQIKLLEX FLGIDLFKRK
     NRSLELTELG KAYFVDINKI LRRLNEATER LLTLKTDPHL NISVPQTFGI QWLVPHLSEF
     NQLYPQIEVR LTGVDQDEGL LNKEIDLAIY YGLGNWQNLQ VDRLCEENLL ILASPELLAE
     NPIIQPEDLK KHTLIHIHTC DNWQAMANHL QLDDLNIQQG PLFSHTFMAL QAAIHGQGIV
     LANRLLALQE IENGSLQAVL PTNLPDPKSF YVVNHLDRLD DQKIQAFRQW IINSIKQEEN
     E