ID   GCVK_HHV6U              Reviewed;         562 AA.
AC   P24446;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Probable ganciclovir kinase;
DE            EC=2.7.1.-;
GN   Name=U69; Synonyms=15R;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2152817; DOI=10.1128/jvi.64.1.287-299.1990;
RA   Lawrence G.L., Chee M., Craxton M.A., Gompels U.A., Honess R.W.,
RA   Barrell B.G.;
RT   "Human herpesvirus 6 is closely related to human cytomegalovirus.";
RL   J. Virol. 64:287-299(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Phosphorylates the antiviral nucleoside analog ganciclovir.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. HCMV ganciclovir subfamily. {ECO:0000305}.
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DR   EMBL; M68963; AAA65577.1; -; Genomic_DNA.
DR   EMBL; X83413; CAA58361.1; -; Genomic_DNA.
DR   PIR; E36769; QQBEH5.
DR   RefSeq; NP_042962.1; NC_001664.2.
DR   PRIDE; P24446; -.
DR   DNASU; 1487950; -.
DR   GeneID; 1487950; -.
DR   KEGG; vg:1487950; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR010615; Herpes_UL97.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   Pfam; PF06734; UL97; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Early protein; Kinase; Nucleotide-binding; Reference proteome;
KW   Transferase.
FT   CHAIN           1..562
FT                   /note="Probable ganciclovir kinase"
FT                   /id="PRO_0000088194"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        313
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10028"
FT   BINDING         201..209
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         218
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   562 AA;  63717 MW;  09111202754CC071 CRC64;
     MDNGVETPQG QKTQPINLPP VRKKLRKHEG LGKGVKRKLF AEDSSPLKKQ ISACSDMETL
     SSPVKSECES RSASLDESFG KCKHEIACDC SAIEELLCHE SLLDSPMKLS NAHTIFSSNK
     WKLELEKIIA SKQIFLDMSE NAELAAYGET LCNLRIFEKI SSPFLFDVQS EERSYSVVYV
     PHNKELCGQF CQPEKTMARV LGVGAYGKVF DLDKVAIKTA NEDESVISAF IAGVIRAKSG
     ADLLSHECVI NNLLISNSVC MSHKVSLSRT YDIDLHKFED WDVRNVMNYY SVFCKLADAV
     RFLNLKCRIN HFDISPMNIF LNHKKEIIFD AVLADYSLSE MHPNYNGTCA IAKEYDKNLQ
     LVPISRNKFC DMFNPGFRPL VANAMILVNV CGAFDGENNP LRHCNLDLCA FAQVVLSCVL
     RMTDKRGCRE AQLYYEKRLF ALANEACRLN PLKYPFAYRD ACCKVLAEHV VLLGLLFYRD
     VVEIYEKLYD FLDERGEFGS RDLFEATFLN NSKLTRRQPI REGLASLQSS EYGEKLLHDL
     RELFLINSTA DLDKDTSSLF HM