ID   GCVK_HHV6Z              Reviewed;         563 AA.
AC   P52446; Q9IBR7;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2003, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Probable ganciclovir kinase;
DE            EC=2.7.1.-;
GN   Name=U69; Synonyms=CH2R;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 284-563.
RX   PubMed=8634027; DOI=10.1007/bf01718406;
RA   Lindquester G.J., Inoue N., Allen R.D., Castelli J.W., Stamey F.R.,
RA   Dambaugh T.R., O'Brian J.J., Danovich R.M., Frenkel N., Pellett P.E.;
RT   "Restriction endonuclease mapping and molecular cloning of the human
RT   herpesvirus 6 variant B strain Z29 genome.";
RL   Arch. Virol. 141:367-379(1996).
CC   -!- FUNCTION: Phosphorylates the antiviral nucleoside analog ganciclovir.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. HCMV ganciclovir subfamily. {ECO:0000305}.
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DR   EMBL; AF157706; AAD49670.1; -; Genomic_DNA.
DR   RefSeq; NP_050248.1; NC_000898.1.
DR   PRIDE; P52446; -.
DR   DNASU; 1497069; -.
DR   GeneID; 1497069; -.
DR   KEGG; vg:1497069; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR010615; Herpes_UL97.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   Pfam; PF06734; UL97; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..563
FT                   /note="Probable ganciclovir kinase"
FT                   /id="PRO_0000088195"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        314
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10028"
FT   BINDING         202..210
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         219
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   563 AA;  63884 MW;  22C6F87A346432C2 CRC64;
     MDNGVETPQG QKTQPINLPP DRKRLRKHDG LGKGVKRKLF AEDSSPLKKQ IPACSDMETL
     SSPVKFGCKS RSASALDESF GKCKHETACD CSAIEELLCH ESLLDSPMKL SNAHTIFSSD
     KWKLELEKII ASKQIFLDMS ENVELVAYGE TLCNLRIFEK ISSPFLFDVQ SEERSYSVVY
     VPHNKELCGQ FCQPEKTMAR VLGVGAYGKV FDLDKVAIKT ANEDESVISA FIAGVIRAKS
     GADLLSHDCV INNLLISNSV CMDHKVSLSR TYDVDLYKFE DWDVRNVMNY YSVFCKLADA
     VRFLNLKCRI NHFDISPMNI FINHKKEIIF DAVLADYSLS EIHPEYNGTC AIAKEYDRNL
     QLVPISRNKF CDMFNPGFRP LVANAMILVN VCEAFDGENN PLRHCNLDLC AFAQVVLLCV
     LRMTDKRGCR EAQLYYEKRL FALANEACRL NPLRYPFAYR DACCKVLAEH VVLLGLLFYR
     DVVDIYEKIY DFLDERGEFG LRDLFEATFL NNSKLTRRQP IRGGLASLQS SEYGEKLLHD
     LRALFLITSS ADLDKDTSSL FQM