ID   GCVK_HHV7J              Reviewed;         546 AA.
AC   P52344;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Probable ganciclovir kinase;
DE            EC=2.7.1.-;
GN   Name=U69;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Phosphorylates the antiviral nucleoside analog ganciclovir.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. HCMV ganciclovir subfamily. {ECO:0000305}.
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DR   EMBL; U43400; AAC54730.1; -; Genomic_DNA.
DR   PIR; T41970; T41970.
DR   RefSeq; YP_073809.1; NC_001716.2.
DR   PRIDE; P52344; -.
DR   DNASU; 3289527; -.
DR   GeneID; 3289527; -.
DR   KEGG; vg:3289527; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR010615; Herpes_UL97.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   Pfam; PF06734; UL97; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Early protein; Kinase; Nucleotide-binding; Reference proteome;
KW   Transferase.
FT   CHAIN           1..546
FT                   /note="Probable ganciclovir kinase"
FT                   /id="PRO_0000088196"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..29
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        297
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10028"
FT   BINDING         185..193
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         202
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   546 AA;  62854 MW;  4D75A01FE4695528 CRC64;
     MEQLKTPQNQ KTRPRNMLPK KKGKELKKRP CKVKRKLFGS ENIRPNKKIP LASDVDNELE
     KKRGSMIRKR SETDLCPDPS VTDLLCHESL TVSPKFERDG LSACTEFENF MDTRKIVLSR
     NEKSVTDLSA HYPVLCNLGI FERIHSPFLF SIHIDTQSFS VVYVPHKESS CSQFCEPEKN
     MARILGSGSY GMVYDLNNVA IKASDDLESC ISSYVSGVVR AKAGAQLTSR ECVFKSLLIC
     NSVCLNHKIS LSKTYDTDLY KFTDWKLENV ENYYSIFCNL AEAVRFLNMV CKINHCDISL
     ANILIHHKEG IILEAVLADY SLAEVHPQYN GKCGILRQFD HRIQIVPKSY NKLCDMFNPG
     FRPMIAHKII LVEVYAEFDG KGNPVRHCNL DLCALAQVFL LCVIRMLDER GCREAQKYYE
     NRLFTYSNEA CTLNPIKYPL EYKDACCKVL AEHLVLFGIL FYREVVDMFE NLYDFLHASG
     DLSVRDLLEE TYVNDSRDVR RQPIRYRHAQ LQRHEIGQIL LNDLQQLLSI ITISDLEKDP
     YSVFRV