ID   GCVK_SHV21              Reviewed;         431 AA.
AC   Q01015;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Probable ganciclovir kinase;
DE            EC=2.7.1.-;
GN   Name=36;
OS   Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=10383;
OH   NCBI_TaxID=9521; Saimiri sciureus (Common squirrel monkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1321287; DOI=10.1128/jvi.66.8.5047-5058.1992;
RA   Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B.,
RA   Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B.,
RA   Honess R.W.;
RT   "Primary structure of the herpesvirus saimiri genome.";
RL   J. Virol. 66:5047-5058(1992).
CC   -!- FUNCTION: Phosphorylates the antiviral nucleoside analog ganciclovir.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. HCMV ganciclovir subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00159}.
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DR   EMBL; X64346; CAA45659.1; -; Genomic_DNA.
DR   RefSeq; NP_040238.1; NC_001350.1.
DR   PRIDE; Q01015; -.
DR   GeneID; 1682483; -.
DR   KEGG; vg:1682483; -.
DR   Proteomes; UP000000587; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase;
KW   Tyrosine-protein kinase.
FT   CHAIN           1..431
FT                   /note="Probable ganciclovir kinase"
FT                   /id="PRO_0000088197"
FT   DOMAIN          79..368
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        195
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10028"
FT   BINDING         85..93
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         103
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   431 AA;  48904 MW;  8D8B3CB048735BFD CRC64;
     MASPHPRKKR IVQKLPSLTQ SCNGELRPCP ECLQPHFSKI PILSQLITEH KFMCVSEISA
     HKVVFKLPKS WFQCEHLKPQ EDAVLGSGSF GSVKPISKVT CAKYFTDPVD FYHELIACNL
     AALAQIRNST RAIYLVRMTG AYIPCKCILF PRYAGSLYDF KCWDKISAKK LAKEFKSLVN
     AVNFLNDEVG IIHSDISTSN ILVAHGPDFP GTFLLADLGV ASLHSGNHQT ELCVKNSRGK
     ILYNMSCTRD IFLLCKDPVK PAQVIFRCYL LACKLINSET LHQTFIVGKI LAQNIDMASL
     FYTMLECVEK MLDTKDIKPS REFYNKIGPD DESHKAYFLQ FLVPRVVLLE MLSRLWDTKL
     SIGIDSFGNT TEKNVLEVQD KILFASWCTH LKGFLHKGGL QLNLNKLRAQ PLYELVRFFL
     KFDYFSLSGR Q